Preparation of Poly(ε-caprolactone)/Poly(ester amide)Electrospun Membranes for Vascular Repair  

作　　者：ZHANG Xiangyu BAI Shan ZANG Leilei CHEN Xiaoqi YUAN Xiaoyan 

机构地区：[1]School of Materials Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin,300350,P.R.China [2]Institute of Energy Resources,Hebei Academy of Sciences,Shijiazhuang,050081,P.R.China

出　　处：《Chemical Research in Chinese Universities》2022年第4期1111-1117,共7页高等学校化学研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.52073204).

摘　　要：With adjustable amphiphilicity and anionic/cationic charge,biodegradability and biocompatibility,amino acid-based poly(ester amide)s(PEAs)have drawn attention in the research of tissue engineered vascular grafts.In this work,L-phenylalanine-based PEAs with or without L-lysine were synthesized through polycondensation,and ultrafine fibrous grafts consisted of PEAs and poly(ε-caprolactone)(PCL)in given mass ratios were further prepared via blend electrospinning.Surface characterizations by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed the chemical structure,and the wettability indicated that the prepared PCL/PEAs electrospun membranes exhibited less hydrophobic than PCL.Tensile results showed that the PCL/PEAs membranes possessed suitable mechanical properties,which could meet the requirements of artificial blood vessels.Cell culture and hemolytic tests exhibited that the PCL/PEAs electrospun membranes are biocompatible.In general,the electrospun grafts of PCL/PEAs could be applied for vascular repair.

关 键 词：Poly(ester amide) Poly(ε-caprolactone) Electrospun membrane Mechanical property Vascular repair 

分 类 号：O62[理学—有机化学]