阿莫西林克拉维酸钾分散片治疗小儿化脓性扁桃体炎的效果分析  

Curative effect of amoxicillin and clavulanate potassium dispersible tablets on suppurative tonsillitis in children

作　　者：李丽[1] 周涛[2] Li Li;Zhou Tao(Department of Pain,Central Hospital of China Railway 17th Bureau Group City Construction Co.,Ltd,Taiyuan 030032,China;Department of Pediatrics,Taierzhuang District People’s Hospital,Zaozhuang 277400,China)

机构地区：[1]中铁十七局集团有限公司中心医院疼痛科,太原030032 [2]枣庄市台儿庄区人民医院儿科,枣庄277400

出　　处：《中国实用医刊》2022年第9期82-85,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨阿莫西林克拉维酸钾分散片治疗小儿化脓性扁桃体炎的临床疗效。方法抽取2018年5月至2021年5月中铁十七局集团有限公司中心医院收治的小儿化脓性扁桃体炎患儿98例,按照随机数字表法分为观察组与对照组,每组49例。对照组采用阿奇霉素治疗,观察组采用阿莫西林克拉维酸钾分散片治疗。比较两组治疗效果、症状缓解时间、不良反应发生情况及治疗前后C反应蛋白(CRP)、白细胞计数(WBC)、中性粒细胞(NE)水平。结果观察组总有效率(95.92%,47/49)高于对照组(83.67%,41/49),P<0.05。观察组体温恢复时间、咽痛消失时间、扁桃体脓性分泌物消失时间、扁桃体充血消退时间均短于对照组(P均<0.05)。治疗前,两组CRP、WBC及NE比较差异未见统计学意义(P>0.05);治疗后,观察组CRP、WBC低于对照组(P<0.05),但两组NE比较差异未见统计学意义(P>0.05)。观察组不良反应发生率(4.08%,2/49)低于对照组(16.33%,8/49),P<0.05。结论相比阿奇霉素方案,小儿化脓性扁桃体炎采用阿莫西林克拉维酸钾分散片治疗,不仅可提高疗效,减少不良反应,且可以缩短症状缓解时间,改善CRP与WBC水平。Objective To investigate the clinical efficacy of amoxicillin and clavulanate potassium dispersible tablets in the treatment of pediatric suppurative tonsillitis.Methods A total of 98 children with purulent tonsillitis treated in Central Hospital of China Railway 17th Bureau Group City Construction Co.,Ltd.from May 2018 to May 2021 were included in this study.And they were divided into observation group and control group by random number table method,with 49 cases in each group.The control group was treated with azithromycin,and the observation group was treated with amoxicillin and clavulanate potassium dispersible tablets.The efficacy,symptom relief time,preoperative adverse reactions and postoperative levels of C-reactive protein(CRP),white blood cell count(WBC)and neutrophils(NE)were compared between the two groups.Results The total effective rate of the observation group(95.92%,47/49)was higher than that of the control group(83.67%,41/49),P<0.05.The recovery time of body temperature,disappearance time of pharyngeal pain,disappearance time of tonsil purulent secretion,and regression time of tonsil congestion in the observation group were shorter than those in the control group(all P<0.05).There was no significant difference in levels of CRP,WBC and NE between the two groups before treatment(P>0.05).After treatment,levels of CRP and WBC in the observation group were lower than those in the control group(P<0.05),but there was no significant difference in NE level between the two groups(P>0.05).The adverse reaction rate of the observation group(4.08%,2/49)was lower than that of the control group(16.33%,8/49),P<0.05.Conclusions Compared with azithromycin regimen,amoxicillin and clavulanate potassium dispersible tablets in the treatment of children with purulent tonsillitis can improve the efficacy,reduce adverse reactions,shorten the time of symptom relief,and improve CRP and WBC levels.

关 键 词：扁桃体炎 阿莫西林克拉维酸钾分散片 阿奇霉素 症状缓解时间 

分 类 号：R766.18[医药卫生—耳鼻咽喉科]