碳酸锂联合丙基硫氧嘧啶治疗甲状腺功能亢进的效果观察  

Clinical efficacy of lithium carbonate combined with propylthiouracil in the treatment of hyperthyroidism

作　　者：孙玲[1] 赵艳利[1] 汪湲[1] 康志强[1] Sun Ling;Zhao Yanli;Wang Yuan;Kang Zhiqiang(Department of Endocrine,Zhengzhou Central Hospital,Zhenghou 450000,China)

机构地区：[1]郑州市中心医院内分泌科,郑州450000

出　　处：《中国实用医刊》2022年第9期90-93,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析碳酸锂联合丙基硫氧嘧啶治疗甲状腺功能亢进的效果。方法抽取2016年2月至2021年5月郑州市中心医院收治的甲状腺功能亢进患者64例,按照用药方案分为联合组和单一组,每组32例。单一组给予丙基硫氧嘧啶治疗,联合组给予碳酸锂联合丙基硫氧嘧啶治疗。比较两组总有效率、症状评分、甲状腺激素水平[三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)]、甲状腺相关抗体水平、不良反应发生率、生活质量评分。结果联合组总有效率(93.75%,30/32)高于单一组(75.00%,24/32),P<0.05。治疗后,联合组多汗、多食、心悸评分低于单一组(t=38.45、42.45、31.40,P均<0.05)。治疗后,联合组TSH高于单一组(t=32.25,P<0.05),T3、T4、FT3、FT4低于单一组(t=19.71、27.01、38.85、15.43,P均<0.05)。治疗后,联合组甲状腺相关抗体水平低于单一组(P<0.05)。联合组不良反应发生率(9.38%,3/32)与单一组(3.13%,1/32)比较差异未见统计学意义(P>0.05)。治疗后,联合组生活质量评分高于单一组(t=5.12,P<0.05)。结论碳酸锂联合丙基硫氧嘧啶治疗甲状腺功能亢进效果显著,可调节甲状腺激素和抗体表达,改善临床症状和生活质量,且联合用药安全。Objective To analyze the efficacy of lithium carbonate combined with propylthiouracil in the treatment of hyperthyroidism.Methods A total of 64 patients with hyperthyroidism who were admitted to Zhengzhou Central Hospital from February 2016 to May 2021 were selected and divided into combined group and single group according to the medication regimens,with 32 cases in each group.The single group was treated with propylthiouracil,and the combined group was treated with lithium carbonate combined with propylthiouracil.The total effective rate,symptom score,levels of thyroid hormone,including triiodothyronine(T3),thyroxine(T4),thyrotropin(TSH),free triiodothyronine(FT3),free thyroid hormone(FT4),levels of thyroid-related antibody,incidence of adverse reactions,and quality of life scores were compared between the two groups.Results The total effective rate of the combined group(93.75%,30/32)was higher than that of the single group(75.00%,24/32),P<0.05.After treatment,the scores of hyperhidrosis,polyphagia and palpitations in the combined group were lower than those in the single group(t=38.45,42.45,31.40;all P<0.05).After treatment,the TSH in the combined group was higher than that in the single group(t=32.25,P<0.05),and the T3,T4,FT3,and FT4 were lower than those in the single group(t=19.71,27.01,38.85,15.43;all P<0.05).After treatment,the levels of thyroid-related antibodies in the combined group were lower than those in the single group(P<0.05).There was no significant difference in the incidence of adverse reactions between the combination group(9.38%,3/32)and the single group(3.13%,1/32),P>0.05.After treatment,the activities of daily living score in the combined group was higher than that in the single group(t=5.12,P<0.05).Conclusions Lithium carbonate combined with propylthiouracil has a significant effect in the treatment of hyperthyroidism;it can regulate the expression of thyroid hormones and antibodies and improve clinical symptoms and quality of life,with high safety.

关 键 词：甲状腺功能亢进 碳酸锂 丙基硫氧嘧啶 甲状腺激素 甲状腺抗体 

分 类 号：R581.1[医药卫生—内分泌]