腹膜透析和血液透析治疗慢性肾功能衰竭合并不宁腿综合征的效果比较  

Comparison on effect of peritoneal dialysis versus hemodialysis on restless legs syndrome in patients with chronic renal failure

作　　者：孙夕然 王萌萌 张靖华[1] Sun Xiran;Wang Mengmeng;Zhang Jinghua(Department of Nephrology,the 7th People’s Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市第七人民医院肾内科,郑州450000

出　　处：《中国实用医刊》2022年第10期65-68,共4页Chinese Journal of Practical Medicine

摘　　要：目的对比分析腹膜透析和血液透析治疗慢性肾功能衰竭(CRF)合并不宁腿综合征(RLS)的效果。方法抽取2018年3月至2021年7月郑州市第七人民医院收治的CRF合并RLS患者78例,采用随机数字表法分为腹膜透析组与血液透析组,每组39例。血液透析组采用血液透析治疗,腹膜透析组采用腹膜透析治疗。比较两组疗效、国际RLS研究组评分量表(IRLS)评分、肾功能、钙磷代谢水平、匹兹堡睡眠质量量表(PSQI)评分、生活质量综合评定问卷-74(GQO74L)评分。结果腹膜透析组总有效率为92.31%(36/39),高于血液透析组的74.36%(29/39),P<0.05。治疗后,腹膜透析组IRLS评分[(11.53±1.02)分]低于血液透析组[(15.75±1.35)分],P<0.05。治疗后,两组尿素氮水平比较差异未见统计学意义(P>0.05),但腹膜透析组β2-微球蛋白水平[(26.41±2.71)ng/L]低于血液透析组[(35.84±3.25)ng/L],P<0.05。两组治疗前后钙磷代谢水平比较差异未见统计学意义(P>0.05);治疗后,腹膜透析组PSQI评分低于血液透析组,GQO74L评分高于血液透析组(P<0.05)。结论与血液透析相比,腹膜透析治疗CRF合并RLS的效果显著,可改善肾功能,减轻RLS严重程度和对睡眠质量、生活质量的影响。Objective To compare and analyze the application effect of peritoneal dialysis and hemodialysis in the treatment of restless legs syndrome(RLS)in patients with chronic renal failure(CRF).Methods A total of 78 patients with CRF complicated by RLS treated in the 7th People’s Hospital of Zhengzhou from March 2018 to July 2021 were selected,and the patients were divided into peritoneal dialysis group and hemodialysis group according to random number table method,with 39 cases in each group.Hemodialysis was used in the hemodialysis group,and peritoneal dialysis was used in the peritoneal dialysis group.The efficacy,international restless legs team rating scale(IRLS)score,renal function,calcium and phosphate metabolism level,Pittsburgh sleep quality scale(PSQI)score and generic quality of life inventory-74(GQO74L)score were compared between the two groups.Results The total effective rate in the peritoneal dialysis group was 92.31%(36/39),which was higher than 74.36%(29/39)in the hemodialysis group(P<0.05).After treatment,the IRLS score of the peritoneal dialysis group(11.53±1.02)was lower than that of the hemodialysis group(15.75±1.35),P<0.05.There was no significant difference in urea nitrogen between the two groups after treatment(P>0.05),but the level ofβ2-microglobulin in the peritoneal dialysis group was(26.41±2.71)ng/L,lower than(35.84±3.25)ng/L in the hemodialysis group(P<0.05).There was no significant difference in calcium and phosphate metabolism levels between the two groups before and after treatment(P>0.05).Compared with the hemodialysis group after treatment,the peritoneal dialysis group had a lower PSQI score and a higher GQO74L score(P<0.05).Conclusions Compared with hemodialysis,peritoneal dialysis has a significant effect in the treatment of patients with CRF complicated by RLS.It can improve renal function,reduce the severity of RLS,and decrease the impact on sleep quality and quality of life.

关 键 词：肾功能衰竭 不宁腿综合征 腹膜透析 血液透析 

分 类 号：R692.5[医药卫生—泌尿科学]