能量失衡调节kisspeptin系统的可能机制  

Possible mechanisms of energy imbalance regualting kisspeptin system

作　　者：徐瑞 曹友祥 夏秋 XU Rui;CAO You-xiang;XIA Qiu(School of Sports and Health,Nanjing Sport Institute,Nanjing 210014,China;Laboratory of Kinesiology,Nanjing Sport Institute,Nanjing 210014,China;School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China)

机构地区：[1]南京体育学院运动健康学院,江苏南京210014 [2]南京体育学院运动人体科学实验室,江苏南京210014 [3]上海体育学院运动科学学院,上海200438

出　　处：《中国病理生理杂志》2022年第7期1311-1319,共9页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.32071173);江苏省教育厅资助项目(No.19KJB180018);南京体育学院实验室开放课题(No.SY202102)。

摘　　要：能量稳态是维持生殖功能正常的重要前提。不论是能量过剩的正能量平衡状态还是能量缺失的负能量平衡状态都会对生殖功能产生影响。肥胖会导致女性出现多囊卵巢综合征,男性发生睾丸病变、精子活力降低以及不育等问题;禁食、营养不良则会导致促性腺激素分泌低下、不育症以及女性出现下丘脑性闭经等。Kisspeptin system in the hypothalamus is not only a major player in the activation of the hypothalamic-pituitary-gonadal axis at puberty and maintenance of reproductive capacity in mammals,but also a sensor of energy status of the body. In the conditions of energy imbalance,the metabolic hormones/factors,such as leptin,adiponectin,insulin,ghrelin,AMP-activated protein kinase(AMPK),and mammalian target of rapamycin(mTOR),could affect the kisspeptin system in hypothalamus both directly and indirectly via a complex network of other neurons,such as proopiomelanocortin(POMC)and agouti-related peptide(AgRP),and subsequently regulate the release of gonadotropins. In this review article,we have provided an updated summary of the available literatures on the regulation of the hypothalamic kisspeptin system by metabolism hormones/factors,so as to provide help in subsequent studies.

关 键 词：kisspeptin系统 能量平衡 代谢激素 代谢因子 

分 类 号：R589[医药卫生—内分泌] R363.2[医药卫生—内科学]