原发性膝骨关节炎易感基因多态性位点的系统综述  

Susceptibility gene polymorphisms of primary knee osteoarthritis:a systematic review

作　　者：罗盛飞 胡志波 王宁华[3] 闵红巍[4,5] 张德俭[4] 刘克敏[4,5] LUO Shengfei;HU Zhibo;WANG Ninghua;MIN Hongwei;ZHANG Dejian;LIU Kemin(The Second Hospital of Tianjin Medical University,Tianjin 300211,China;Tianjin Medical University,Tianjin 300134,China;The First Hospital of Peking University,Beijing 100034,China;China Rehabilitation Research Center,Beijing Bo'ai Hospital,Beijing 100068,China;Capital Medical University School of Rehabilitation Medicine,Beijing 100068,China)

机构地区：[1]天津医科大学第二医院,天津市300211 [2]天津医科大学,天津市300134 [3]北京大学第一医院,北京市100034 [4]中国康复研究中心北京博爱医院,北京市100068 [5]首都医科大学康复医学院,北京市100068

出　　处：《中国康复理论与实践》2022年第7期803-808,共6页Chinese Journal of Rehabilitation Theory and Practice

基　　金：中央级公益性科研院所基础科研业务经费专项资金项目(No.2019CZ-12)。

摘　　要：目的对原发性膝骨关节炎(PKO)易感基因多态性位点进行系统综述。方法检索PubMed、Web of Science、中国知网、万方数据库和中国生物医学文献数据库从建库至2020年12月有关PKO遗传易感性与基因多态性的文献,进行系统综述。结果纳入有关人类PKO易感基因多态性位点的文献共42篇,涉及有关PKO发病的细胞信号通路包括炎症反应、受体信号通路、转录因子信号通路、骨相关信号通路等,包括炎症因子基因、趋化因子基因、Toll样受体基因、转录因子基因、肥胖相关基因、骨相关基因等多个基因多态性位点。结论炎症因子基因和骨相关等位基因多态性很可能与PKO易感性有关。Objective To conduct a systematic review of the susceptibility gene polymorphism sites of primary knee osteoarthritis(PKO).Methods The literature on genetic susceptibility and gene polymorphisms of PKO were retrieved from PubMed,Web of Science,CNKI,Wanfang Data,and China Biomedical Literature Database from establishment of the library to December,2020,and systematically reviewed.Results A total of 42 papers on the polymorphism sites of human PKO susceptibility genes were included,involving cellular signaling pathways related to PKO pathogenesis,including inflammatory response,receptor signaling pathway,transcription factor signaling pathway,bone-related signaling pathway,etc.Multiple gene polymorphism sites located in inflammatory factor genes,chemokine genes,Toll-like receptor genes,transcription factor genes,obesity-related genes,and bone-related genes.Conclusion Inflammatory factor genes and bone-associated allele polymorphisms are likely to be related to PKO susceptibility.

关 键 词：原发性膝骨关节炎 遗传易感性 单核苷酸多态性 治疗靶点 系统综述 

分 类 号：R684.3[医药卫生—骨科学]