HIV确诊到治疗间隔对短期抗病毒治疗后血常规及肝肾功能的影响  

Effects of short-term antiretroviral therapy on blood routine, liver and kidney function between HIV patients’ interval from diagnosis to ART

作　　者：邱渊 陈仁富 颜惠丽 黄云逸 于德娥[2,3] QIU Yuan;CHEN Ren-fu;YAN Hui-li;HUANG Yun-yi;YU De-e(Haikou Prevention and Treatment Center of Municipal Dermatosis Diseases,Venereal Disease and Mental Diseases,Haikou,Hainan 570102,China;International School of Public Health and One Health&Heinz Mehlhorn Academician Workstation,Hainan Medical University,Haikou,Hainan,571199,China;Public health department of Guangxi Medical University&Guangxi key laboratory for AIDS prevention and treatment,Nanning Guangxi 530021,China)

机构地区：[1]海口市皮肤病性病和精神病防治所,海南海口570102 [2]海南医学院公共卫生与全健康国际学院Heinz Mehlhorn院士工作站,海南海口571199 [3]广西医科大学公共卫生学院广西艾滋病防治研究重点实验室,广西南宁530021

出　　处：《中国热带医学》2022年第4期329-334,338,共7页China Tropical Medicine

基　　金：广西壮族自治区研究生教育创新计划项目(No.YCBZ2021042)。

摘　　要：目的了解HIV感染者从确诊到接受抗病毒治疗(antiretroviral therapy,ART)间隔的影响因素,探讨不同间隔对短期治疗后血常规及肝肾功能的影响。方法收集海口市2017—2021年接受ART的HIV感染者的病案信息,将感染者从确诊到接受ART的间隔分为≤30 d、>30~60 d、>60~365 d和>365 d 4组,比较不同组间ART 1个月后血常规和肝肾功能的差异。结果在302例病例中,男性91.7%,确诊60 d内进行ART者为71.8%;确诊时6.8%的人合并乙肝,3.6%的人感染过肺结核。影响因素分析发现,各组仅在性别和确诊时间上有统计学差异(P<0.05)。各组的基线平均红细胞血红蛋白含量和总蛋白差异有统计学意义(P<0.05),均是>30~60 d组含量低于其他组。治疗1个月后,各组血常规的各项指标变化差异无统计学意义(P>0.05);在肝肾功能方面,各组白蛋白含量均有增加,分别是0.02 U/L、1.91 U/L、3.67 U/L和2.62 U/L,各组间差异有统计学意义(P<0.05)。结论性别和确诊时间是影响确诊到ART间隔的因素,时间间隔对白蛋白含量有影响。ObjectiveTo understand the risk factors of HIV patients’ interval from diagnosis to ART, and to explore the effects on blood routine, liver and kidney function after short-term antiretroviral therapy(ART).Methods record information of HIV patients receiving ART in Haikou were collected from 2017 to 2021, and the interval from diagnosis to ART was divided into 4 groups: ≤30 days, >30-60 days, >60-365 days and >365 days. The differences of blood routine, liver and kidney function after one month therapy were compared between different groups.Results91.7% were male of all, 71.8% subjects had accepted ART within 60 days after diagnosis. At the time of diagnosis, 6.8% had hepatitis B and 3.6% had tuberculosis. Analysis of influencing factors showed that only gender and time of diagnosis had significant differences(P<0.05). The baseline of content of hemoglobin and total protein had difference among four groups,>30-60 days group was lowest among four groups. After one month of ART, there was no difference in blood routine indexes among all groups(P>0.05). The liver and kidney function showed that total albumin content increased in all groups(0.02 U/L,1.91 U/L, 3.67 U/L and 2.62 U/L, respectively), with statistical significance(P<0.05).Conclusion interval from diagnosis to ART were gender and time of diagnosis, and total albumin were influenced by interval.

关 键 词：AIDS/HIV 抗病毒治疗 血常规 肝肾功能 

分 类 号：R512.91[医药卫生—内科学]