基于COMSOL的乳腺癌光热成像的可视化研究  

Visualization for photothermal imaging of breast cancer based on COMSOL

作　　者：宋贤林 李昱黎 魏剑霜 赖叶平 SONG Xianlin;LI Yuli;WEI Jianshuang;LAI Yeping(School of Information Engineering,Nanchang University,Nanchang 330031,China;Institute of Advanced Studies,Nanchang University,Nanchang 330031,China;Wuhan National Laboratory for Optoelectronics,Huazhong University of Science and Technology,Wuhan 430074,China)

机构地区：[1]南昌大学信息工程学院,江西南昌330031 [2]南昌大学高等研究院,江西南昌330031 [3]华中科技大学武汉光电国家研究中心,湖北武汉430074

出　　处：《华中科技大学学报（自然科学版）》2022年第5期84-88,共5页Journal of Huazhong University of Science and Technology(Natural Science Edition)

基　　金：国家自然科学基金青年基金资助项目(41906171).

摘　　要：利用有限元模拟软件COMSOL Multiphysics设计了乳腺癌光热成像可视化模型,该模型研究了光在乳腺癌患者乳房中的传播和热传递情况.首先构建了乳房的简化模型并进行网格划分,随后对COMSOL中系数形式偏微分方程和生物传热模块进行耦合.将系数形式偏微分方程简化近似为亥姆霍兹方程,对光在乳房及肿瘤中的传播进行可视化模拟,生物传热模块对光能量吸收导致的温度变化进行可视化.仿真结果表明:肿瘤处剩余光能量约为周围乳房组织剩余光能量的1.524%.肿瘤吸收的更多光能量导致其温度显著高于周围乳房组织的温度,温度差约为0.06 K.肿瘤中心的温度低于肿瘤边缘的温度,同时肿瘤靠近光源一侧的温度高于远离光源一侧的温度.该研究有助于理解光在人体乳房和乳腺肿瘤中的传播及相互作用,对乳腺癌的光热治疗有一定指导意义.A visualization model for the photothermal imaging of breast cancer was developed using COMSOL Multiphysics,and the model studied the light propagation and heat transfer in the breast cancer.First,a simplified model of the breast was constructed and meshed,and then the coefficient form partial differential equation in the COMSOL was coupled with the biological heat transfer module.The coefficient form partial differential equation was simplified and approximated to Helmholtz equation for the visualization of light propagation in breast and tumor,and the temperature changes caused by optical absorption was visualized by the biological heat transfer module.Simulation results show that the residual light energy in the tumor is about 1.524%of that of the surrounding breast tissue.The light energy absorbed by the tumor results in a temperature significantly higher than that of the surrounding breast tissue,with a temperature difference of about 0.06 K.The temperature in the center of the tumor is lower than the temperature at the edge of the tumor,meanwhile,the temperature of the side near the light source is higher than that of the side away from the light source.This study is helpful to understand the propagation and interaction of light in human breast and breast tumors,and has certain guiding significance for the photothermal treatment of breast cancer.

关 键 词：光热成像 乳腺癌 COMSOL 光沉积 热传递 可视化 

分 类 号：Q63[生物学—生物物理学]