生长因子调控创面修复的进展与思考  

Progress and thoughts on the regulation of wound repair by growth factors

作　　者：肖健 张凡 Xiao Jian;Zhang Fan(Department of Wound Repair,the First Affiliated Hospital of Wenzhou Medical University,Wound Repair and Regenerative Medicine Center,Wenzhou Medical University,School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou 325035,China)

机构地区：[1]温州医科大学附属第一医院创面修复科,温州医科大学创伤修复与再生医学中心,温州医科大学药学院,温州325035

出　　处：《中华烧伤与创面修复杂志》2022年第7期610-615,共6页Chinese Journal of Burns And Wounds

基　　金：国家自然科学基金优秀青年科学基金项目(81722028);温州市重大科技创新攻关项目(ZY2020023)。

摘　　要：生长因子在创面愈合中起重要调控作用,其主要通过激活相关信号通路加速创面愈合。中国科学家对生长因子的基础、临床研究至今已有30年历史,研发的生长因子系列药物被广泛应用于烧创伤及慢性难愈合溃疡的治疗。该文从免疫、神经、脂肪等多个角度阐述了生长因子对创面修复的前沿进展,并提出了该研究团队对生长因子调控创面修复的进一步思考。Growth factors play an important role in wound healing,and they mainly accelerate wound healing by activating the related signal pathways.Chinese scientists have been conducting basic and clinical researches on growth factors for 30 years,with a series of growth factor drugs being developed and widely used in the treatment of burns and trauma and chronic refractory ulcers.This paper expounds the frontier progress of growth factors on wound healing from the perspectives of immunity,nerve,fat,and so on,and puts forward the further thoughts of the research team on the regulation of wound healing by growth factors.

关 键 词：生长因子 创面修复 创面愈合 研究团队 前沿进展 信号通路 烧创伤 

分 类 号：R641[医药卫生—外科学]