生物材料递送生长因子调控创面修复的研究进展  

Research advances on biomaterials for the delivery of growth factors to regulate wound repair

作　　者：翁婷婷 蔡程浩 韩春茂[2] 王新刚[2] Weng Tingting;Cai Chenghao;Han Chunmao;Wang Xingang(The Second Clinical College,College of Medicine,Zhejiang University,Hangzhou 310009,China;Department of Burn and Wound Repair,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China)

机构地区：[1]浙江大学医学院第二临床学院,杭州310009 [2]浙江大学医学院附属第二医院烧伤与创面修复科,杭州310009

出　　处：《中华烧伤与创面修复杂志》2022年第7期691-696,共6页Chinese Journal of Burns And Wounds

基　　金：国家重点研发计划(2016YFC1100803);国家自然科学基金面上项目(81772069);王正国创伤医学发展基金会生长因子复兴计划(SZYZ-TR-12)。

摘　　要：创面修复是一个由多种细胞、细胞外基质、细胞因子等共同参与、高度协调又相互调控的复杂过程。多种生长因子在创面修复过程中发挥重要调控作用,而实现生长因子有效递送和功能持续发挥是至关重要的。近年来,生物材料在组织工程中的应用显示出巨大潜力,生物材料对生长因子的有效递送也日益受到关注。基于此,该文介绍了相关生长因子在创面修复过程中的作用机制,并重点讨论了生物材料递送生长因子加速创面愈合的最新进展,以期为临床上创面治疗提供新的启示。Wound repair is a highly coordinated and mutually regulated complex process involving various kinds of cells,extracellular matrices and cytokines.A variety of growth factors play an important regulatory role in wound healing,and it is critical to achieve effective delivery and sustained function of growth factors.In recent years,the application of biomaterials in tissue engineering has shown great potential,and the effective delivery of growth factors by biomaterials has attracted increasing attention.Based on this,this paper introduces the mechanism of related growth factors in the process of wound healing,focusing on the recent progress of biomaterial delivery of growth factors to accelerate wound healing,in order to provide new enlightenment for clinical wound treatment.

关 键 词：伤口愈合 生物相容性材料 组织工程 皮肤 生长因子 

分 类 号：R318.08[医药卫生—生物医学工程]