多沙唑嗪联合托特罗定对合并下尿路感染的老年帕金森病下尿路症状改善的研究  

Effect of doxazosin combined with tolterodine on the improvement of lower urinary tract symptoms in elderly Parkinsons disease patients with lower urinary tract infection

作　　者：胡小龙 张龙 波沈林 高劲松 冯岗 Hu Xiaolong;Zhang Longbo;Shen Lin;Gao Jinsong;Feng Gang(Department of Urology,the People's Hospital of Wanzhou District,Chongqing 404000,China)

机构地区：[1]重庆市万州区人民医院泌尿外科,重庆404000

出　　处：《国际泌尿系统杂志》2022年第4期666-669,共4页International Journal of Urology and Nephrology

摘　　要：目的探讨多沙唑嗪联合托特罗定治疗伴下尿路感染的老年帕金森病(PD)患者的疗效及其对尿流动力学的影响.方法收集2016年3月至2017年11月在本院治疗的84例伴下尿路感染的老年PD患者的临床资料,根据随机数字表法分为对照组(42例,口服多沙唑嗪)和观察组(42例,口服多沙唑嗪和托特罗定).比较两组患者治疗前后的国际前列腺症状评分(IPSS)、生存质量(QOL)评分、最大尿流率(Q_(max))、夜尿次数、尿失禁次数、尿急发作次数等指标.结果两组患者治疗前的IPSS、QOL评分及Q_(max)比较,差异均无统计学意义(均P>0.05);观察组患者治疗后的IPSS、QOL评分及Q_(max)显著低于对照组,差异均有统计学意义(均P<0.01).观察组患者治疗后的夜尿次数、尿失禁次数、尿急发作次数、排尿次数均显著少于对照组(均P<0.01),两组治疗后的剩余尿量、最大膀胱容量比较,差异均无统计学意义(均P>0.05),而治疗后观察组在排尿开始时的膀胱压低于对照组,膀胱顺应性显著高于对照组,差异均有统计学意义(均P<0.05).结论多沙唑嗪联合托特罗定可缓解老年PD患者合并下尿路感染的症状,且可有效改善尿流动力学,值得临床借鉴.Objective To doxazosin combined with Luoding patients with lower urinary tract infection in elderly patients and the effect of Parkinson's disease(PD)on urodynamic.Methods Clinical data of 84 elderly PD patients with lower urinary tract infection treated in our hospital from March 2016 to November 2017 were selected,and they were divided into control group(42 cases,oral doxazosin)and observation group(42 cases,oral doxazosin and tolterodine)according to random number table method.International prostatic symptom scale(IPSS),quality of life(QOL)score,maximum urine flow rate(Q_(max)),nocturia frequency,urinary incontinence frequency,frequency of urgent urination and other indicators were compared between two groups before and after treatment.Results There were no statistically significant differences in IPSS,QOL score and Q_(max) between two groups before treatment(all P>0.05).IPSS,QOL scores and Q_(max)in observation group were significantly lower than those in control group after treatment,with statistical significance(all P<0.01).The frequency of nocturia,urinary incontinence,urgent urination and urination after treatment in the observation group were significantly lower than those in the control group(all P<0.01),two groups of residual urine volume,the maximum bladder capacity comparison after treatment,there were no statistically significant difference(P>0.05),while the observation group in the control group,at the beginning of the urine bladder down bladder compliance was significantly higher than that of control group,the differences were statistically significant(all P<0.05).Conclusions Doxazosin combined with tolterodine can alleviate the symptoms of lower urinary tract infection in elderly patients with PD,and effectively improve unodynamics,which is worthy of clinical reference.

关 键 词：帕金森病 老年人 酒石酸托特罗定 尿路感染 

分 类 号：R691.3[医药卫生—泌尿科学] R742.5[医药卫生—外科学]