米拉贝隆联合索利纳新治疗膀胱过度活动症的临床研究  

Clinical study of mirabegron combined with solifenacin in the treatment of overactive bladder

作　　者：贺文彦[1] 张芙蓉[2] 张建勋[1] 郭吉军[1] He Wenyan;Zhang Furong;Zhang Jianxun;Guo Jijun(Department,of Urology Yanan People's Hospital,Yau'an 716000,China;Department of Neurology,Affiliated Hospital of Yan'an University,Yan'an 716000,China)

机构地区：[1]延安市人民医院泌尿外科,延安716000 [2]延安大学附属医院神经内科,延安716000

出　　处：《国际泌尿系统杂志》2022年第4期675-678,共4页International Journal of Urology and Nephrology

摘　　要：目的探讨米拉贝隆联合索利纳新治疗膀胱过度活动症(OAB)的疗效及安全性.方法收集2018年10月至2020年10月延安市人民医院及延安大学附属医院收治的120例OAB患者,按照随机数字表法分为索利纳新治疗组(对照组)和米拉贝隆联合索利纳新治疗组(试验组),每组各60例.对照组予以口服索利纳新5 mg,1次/日;试验组予以口服米拉贝隆50 mg,1次/日和索利纳新5 mg,1次/日.分别观察并记录两组患者治疗前、治疗12周后的白天排尿次数、夜间排尿次数、尿急、急迫性尿失禁次数及膀胱过度活动症症状评分(OABSS),通过记录膀胱过度活动症问卷(OAB-q)简表分值来评估OAB对患者生活质量的影响,并统计两组口干、便秘、尿潴留、消化不良、心动过速、高血压的发生率.结果两组治疗12周后的白天排尿次数、夜间排尿次数、尿急、急迫性尿失禁及OABSS评分均较治疗前明显改善(均P<0.01);治疗12周后,试验组的白天排尿次数、夜间排尿次数、尿急、急迫性尿失禁、OABSS评分较对照组明显改善,差异均有统计学意义(t=4.438、2.787、3.630、6.156、5.740,均P<0.05).两组治疗12周后的OAB-q评分较治疗前均明显下降,差异均有统计学意义(t=13.946、25.590,均P<0.01);治疗12周后,试验组的OAB-q评分明显低于对照组,差异有统计学意义(t=8.263,P<0.01).OAB患者的OABSS评分与OAB-q评分呈正相关性(P<0.01).两组口干、便秘、尿潴留、消化不良、心动过速、高血压发生率比较,差异均无统计学意义(均P>0.05).结论米拉贝隆联合索利纳新治疗OAB,较单药相比,不仅可以改善患者的症状和生活质量,也不增加不良反应的发生率,可作为临床治疗OAB的新选择.Objective To investigate the efficacy and safety of mirabegron combined with solifenacin in the treatment of overactive bladder(OAB).Methods A total of 120 OAB patients admitted to Yan'an peoples hospital and affiliated hospital of Yan'an university from October 2018 to October 2020 were randomly divided into solinax new treatment group(control group,n.=60)and mirabe-lon combined solinax new treatment group(experimental group,n=60)according to random number table method.The control group was given solifenacin 5 mg once a day,and the experimental group was given mirabilin 50 mg and solifenacin 5 mg once a day.The diurnal micturition frequency,nocturnal micturition frequency,urgency urinary incontinence frequency and overactive bladder symptom scale(OABSS)score were observed and recorded before and after treatment for 12 weeks.The influence of OAB on the quality of life of patients was evaluated by recording the overactive biadder ques-tionnaive(OAB-q)score.The incidence rates of dry mouth,constipation,urinary retention,dyspepsia,tachycardia and hypertension were compared between the two groups.Results In the control group and the experimental group(within and between groups),the number of daytime urination,nocturnal micturition,urgency urinary incontinence,OABSS score and were significantly improved before treatment(all P<0.01).After 12 weeks of treatment,the times of urination during the day,times of urination at night,urination urgency,urination incontinence and OABSS score in the experimental group were significantly improved compared with the control group,with statistical significance(t=4.438,2.787,3.630,6.156,5.740,all P<0.05).OAB-q scores in both groups decreased significantly after 12 weeks of treatment compared with before treatment,the differences were statistically significant(t=13.946,25.590,P<0.01).After 12 weeks of treatment,OAB-q score of the experimental group was significantly lower than that of the control group,the difference was statistically significant(t=8.263,P<0.01).There was a positive cor

关 键 词：膀胱 过度活动性 米拉贝隆 索利纳新 

分 类 号：R694[医药卫生—泌尿科学]