复方丹参滴丸对老年冠心病患者血流变学、血脂与炎性反应递质的影响  

Effect of Compound Danshen Dripping Pills on Blood Rheology,Blood Lipids and Inflammatory Reaction Transmitters in Elderly Patients with Coronary Heart Disease

作　　者：王树鲜 张红娥 WANG Shuxian;ZHANG Hong'e(Liangcai Street Community Health Service Center,Bincheng District,Binzhou 256658,China)

机构地区：[1]山东省滨州市滨城区梁才街道社区卫生服务中心,山东滨州256658

出　　处：《中国医药指南》2022年第20期30-33,共4页Guide of China Medicine

摘　　要：目的探讨复方丹参滴丸对老年冠心病患者血流变学、血脂及炎性反应递质的影响。方法纳入在我中心接受治疗的146例老年冠心病患者作为研究对象,时间为2019年7月至2020年8月,按照随机数表法分为对照组(n=73)与研究组(n=73)。对照组接受常规治疗法,进行对症治疗,如对心肌循环改善、血脂的调节、降低血压和抗凝等。研究组在对照组基础上增加口服复方丹参滴丸,每日3次,每次10丸,总治疗时间为90 d。对比两组的治疗效果、血液流变学指标、血脂指标(TC、TG、LDL、HDL)以及炎性反应递质。结果研究组治疗有效率(91.78%)高于对照组(78.08%)(P<0.05)。治疗前,两组血液流变学指标比较无差异(P>0.05)。两组在经治疗后的血液流变学指标比治疗前均低(P<0.05)。治疗后,研究组的全血高切黏度、血浆黏度、全血低切黏度、红细胞压积、纤维蛋白原及红细胞沉降率显著均比对照组低,差异有统计学意义(P<0.05)。治疗前,两组血脂指标比较无差异(P>0.05)。两组经治疗后血脂TC、TG及LDL明显降低,HDL水平明显上升,差异有显著性(P<0.05)。治疗后,研究组血清TG、TC及LDL水平比对照组低,HDL比对照组高,差异有统计学意义(P<0.05)。治疗前,两组的TNF-α及IL-6水平比较无差异(P>0.05)。与治疗前对比,两组治疗后的TNF-α及IL-6明显降低,差异有统计学意义(P<0.05)。治疗后,研究组TNF-α及IL-6比对照组低,差异有统计学意义(P<0.05)。结论传统西医结合复方丹参滴丸可改善老年冠心病患者的血流动力学,促使血脂恢复至正常水平,减轻炎性反应,临床效果满意可靠。Objective To investigate the effect of compound danshen dripping pills on blood rheology,blood lipids and inflammatory response transmitters in elderly patients with coronary heart disease.Methods From July 2019 to August 2020,146 elderly patients with coronary heart disease who were treated in our hospital were included as the research objects.According to the numerical randomization method,they were divided into investigators and research groups,with 73 cases in each group.The control group received conventional treatments for symptomatic treatment,such as improving myocardial circulation,regulating blood lipids,lowering blood pressure and anticoagulation.The study group added oral compound danshen dripping pills to the control group,3 times a day,10 pills each time.The total treatment time is 90 days.The therapeutic effect,hemorheology indexes,blood lipid indexes(TC,TG,LDL,HDL)and inflammatory response mediators were compared between the two groups.Results The effective rate of treatment in the study group(91.78%)was higher than that in the control group(78.08%)(P<0.05).Before treatment,there was no significant difference in hemorheological indexes between the two groups(P>0.05).After treatment,the indexes of hemorheology in the two groups were lower than those before treatment(P<0.05).After treatment,the study group’s whole blood high shear viscosity,plasma viscosity,whole blood low shear viscosity,hematocrit,fibrinogen and erythrocyte sedimentation rate were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in blood lipid indexes between the two groups(P>0.05).After treatment in the two groups,blood lipids TC,TG and LDL decreased significantly,HDL levels increased significantly,with significant differences(P<0.05).After treatment,serum TG,TC and LDL levels in the study group were lower than those in the control group,and HDL was higher than the control group,with significant differences(P<0.05).B

关 键 词：冠心病 复方丹参滴丸 老年 血流变学 血脂 炎性反应递质 

分 类 号：R541.4[医药卫生—心血管疾病]