基于泛血管医学探讨盐酸罂粟碱治疗血管痉挛所致缺血的临床研究  

Clinical study of papaverine hydrochloride in the treatment of ischemia caused by vasospasm based on Panvascular Medicine

作　　者：左瑞敏 王大英[2] 陈志帆 路临毅 

机构地区：[1]青海制药有限公司,青海西宁810028 [2]中国人民解放军总医院,北京100039

出　　处：《首都食品与医药》2022年第14期12-16,共5页Capital Food Medicine

摘　　要：在中国人群中,30%的缺血性脑卒中和25%的缺血性心脏病同时伴有下肢动脉粥样硬化性疾病.葛均波院士团队对泛血管疾病进行了系统研究,提出多学科交叉的泛血管疾病研究模式和发展理念,并倡议建立泛血管医学这一新兴学科.血管痉挛是由于血管平滑肌细胞异常收缩,导致血管狭窄,造成血流量减少,器官组织缺血,严重者可造成管腔完全闭塞.痉挛时间过长,可继发血栓形成,血管栓塞.血管痉挛会促进血管再狭窄和动脉粥样硬化等疾病的发生与发展.盐酸罂粟碱是经典的血管扩张药物,用于治疗脑、心及外周血管痉挛所致的缺血,肾、胆或胃肠道等内脏痉挛.此文正是基于泛血管医学来归纳总结近些年关于盐酸罂粟碱的临床应用及相关研究.In the Chinese population,30% of ischemic stroke and 25% of ischemic heart disease are accompanied by lower extremity atherosclerotic disease.The team of Academician Ge Junbo has conducted systematic research on panvascular diseases,proposed a multidisciplinary research model and development concept of panvascular diseases,and proposed the establishment of the emerging discipline of panvascular medicine.Vasospasm is due to abnormal contraction of vascular smooth muscle cells,resulting in stenosis of blood vessels,resulting in reduced blood flow,ischemia of organs and tissues,and in severe cases,complete lumen occlusion.Spasm for too long,can be secondary to thrombosis,vascular embolism.Vasospasm can promote the occurrence and development of diseases such as vascular restenosis and atherosclerosis.Papaverine hydrochloride is a classic vasodilator drug used to treat ischemia caused by cerebral,cardiac and peripheral vasospasm,and visceral spasm such as kidney,gallbladder or gastrointestinal tract.This article is based on pan-vascular medicine to discuss the review of clinical research on papaverine hydrochloride in recent years.

关 键 词：泛血管 血管痉挛 盐酸罂粟碱 冠状动脉痉挛 脑血管痉挛 

分 类 号：R543[医药卫生—心血管疾病]