吲唑衍生物及其生物活性研究进展  

Research Progress in Indazole Derivatives and Their Biological Activities

作　　者：汪从雨 龙雪莎 王钦 王贞超[1,2,3] 欧阳贵平 Wang Congyu;Long Xuesha;Wang Qin;Wang Zhenchao;Ouyang Guiping(School of Pharmaceutical Science,Guizhou University;State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering/Key Laboratory of Ministry of Education,Guizhou University;Guizhou Engineering Laboratory for Synthetic Drugs,Guiyang,550025)

机构地区：[1]贵州大学药学院 [2]贵州大学绿色农药与农业生物工程教育部重点实验室 [3]贵州省合成药物工程实验室,贵阳550025

出　　处：《化学通报》2022年第7期810-815,共6页Chemistry

基　　金：国家自然科学基金项目(21867004,22007022);贵州省科技计划平台项目(黔科合平台人才20185781)和贵州省科技计划项目(黔科合基础-ZZK[2021]重点034)资助。

摘　　要：吲唑衍生物具有抗肿瘤、抗菌、抗炎及治疗骨质疏松等多种生物活性,因此,在药物化学领域受到广泛的关注,具有巨大研究前景及价值。本文总结归纳了近几年来与吲唑衍生物相关的文献,对单取代、双取代及多取代吲唑衍生物及其生物活性的最新研究进展进行了综述,希望能为开发高效低毒的吲唑衍生物提供一定的理论基础。Indazole derivatives have many biological activities such as anti-tumor, antibacterial, anti-inflammatory and treatment of osteoporosis. Therefore, they have attracted extensive attention in the field of pharmaceutical chemistry and have great research prospects and value. This paper summarizes the literature related to indazole derivatives in recent years, and reviews the latest research progress of monosubstituted, disubstituted and polysubstituted indazole derivatives and their biological activities. It is hoped to provide a theoretical basis for the development of high efficiency and low toxicity indazole derivatives.

关 键 词：吲唑衍生物 生物活性 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]