Arbuzov重排反应合成膦酸烷基酯的研究进展  

Research Progress in the Synthesis of Alkyl Phosphonates by Arbuzov Rearrangement Reaction

作　　者：江泽琦 马丽欣 邓德茹 凌永社 Jiang Zeqi;Ma Lixin;Deng Deru;Ling Yongshe(Stale Key Laboratory of NBC Protection for Civilian,Beijing,102205)

机构地区：[1]国民核生化灾害防护国家重点实验室,北京102205

出　　处：《化学通报》2022年第7期816-821,共6页Chemistry

摘　　要：膦酸烷基酯是一类具有多种生物活性的有机磷化合物,在农业和医药化工领域具有广泛的应用。本文介绍了Michaelis-Arbuzov重排反应构建P-C键合成膦酸烷基酯类化合物的方法,着重阐述了通过催化剂、微波、超声波等促进的绿色环保的Arbuzov重排反应。特别是在连续流动条件下通过微反应进行的无溶剂Arbuzov重排反应,能够缩短反应时间,提高反应效率,使膦酸烷基酯的合成具有更广阔的应用前景。As a kind of organic phosphorus compounds with various biological activities, alkyl phosphonates have been widely applied in agriculture and medicine. In this paper, the principle of constructing P-C bond to synthesize alkyl phosphonates by Michaelis-Arbuzov rearrangement reaction is introduced. And the environmentally friendly Arbuzov rearrangement reaction promoted by catalyst, microwave and ultrasonic wave are summarized. Especially, the solvent-free Arbuzov rearrangement reaction by micro-reaction under continuous flow conditions can shorten the reaction time and improve the reaction efficiency, which provides the synthesis of alkyl phosphates with a broader application prospect.

关 键 词：催化剂 P-C键 膦酸烷基酯 Michaelis-Arbuzov重排 微反应技术 

分 类 号：O627.51[理学—有机化学]