壳聚糖及其衍生物作为药物及疫苗载体研究进展  

Review on chitosan and its derivatives as drug and vaccine carriers

作　　者：时铭泽 金政 舒建洪[4,5] 赵凯 SHI Ming-ze;JIN Zheng;SHU Jian-hong;ZHAO Kai(Engineering Research Center of Agricultural Microbiology Technology,Ministry of Education,Heilongjiang University,Harbin 150500;Key Laboratory of Microbiology,College of Heilongjiang Province,School of Life Sciences,Heilongjiang University,Harbin 150080;Institute of Nanobiomaterials and Immunology,School of Life Science,Taizhou University,Taizhou 318000;College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018;Zhejiang Hom-Sun Biotechnology,Co.Ltd.,Shaoxing 312366,China)

机构地区：[1]黑龙江大学农业微生物技术教育部工程研究中心,黑龙江哈尔滨150500 [2]黑龙江大学生命科学学院,黑龙江省普通高校微生物重点实验室,黑龙江哈尔滨150080 [3]台州学院生命科学学院/纳米生物材料与免疫学研究所,浙江台州318000 [4]浙江理工大学生命科学与医药学院,浙江杭州310018 [5]浙江洪晟生物科技股份有限公司,浙江绍兴312366

出　　处：《生物技术》2022年第3期373-379,320,共8页Biotechnology

基　　金：浙江省‘尖兵’‘领雁’研发攻关计划下项目(2022C02031);国家自然科学基金项目(31771000)。

摘　　要：壳聚糖及其衍生物具有低毒、可生物降解、生物相容性好、抑菌、黏膜粘附性等优势,其作为药物和疫苗载体已经被广泛研究。水溶性壳聚糖衍生物作为载体还可以提高蛋白质、多肽类药物的生物利用度。该文综述了壳聚糖及其衍生物作为药物和疫苗载体的优势及其局限性,总结了近年来壳聚糖及其衍生物作为药物和疫苗载体的研究成果,并展望了其应用前景。Chitosan and its derivatives have the advantages of low toxicity,biodegradability,biocompatibility,bacteriostasis and mucosal adhesion.They have been widely studied as drug and vaccine carriers.When chitosan and its derivatives are used as drug and vaccine carriers,drugs or vaccines can be transported to appropriate sites through a variety of ways.At the same time,water-soluble chitosan derivatives can also improve the bioavailability of protein and polypeptide drugs.This paper reviews the advantages and limitations of chitosan and its derivatives as drug and vaccine carriers,summarizes the research results of chitosan and its derivatives as drug and vaccine carriers in recent years,and looks forward to its application prospect.

关 键 词：壳聚糖 壳聚糖衍生物 生物载体 药物递送系统 

分 类 号：Q784[生物学—分子生物学]