转运体生物标志物的研究进展  

Research progress on biomarkers of transporters

作　　者：王嘉馨 林以宁[1] WANG Jiaxin;LIN Yining(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学中药学院,江苏南京211198

出　　处：《药学研究》2022年第7期467-471,共5页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81573836)。

摘　　要：药物转运体介导着药物的吸收、分布及消除等过程,其广泛的底物专属性是产生药物相互作用的主要因素之一。生物标志物作为转运体的底物,能通过自身浓度的变化反映转运体蛋白的功能,具有重要的药理学意义。对生物标志物的研究有助于揭示转运体介导的药物相互作用。本文综述了具有一定代表性的肝肾转运体生物标志物,并讨论了生物标志物在预测转运体参与的药物相互作用过程中的意义、局限性和未来方向。Drug transporters mediated the absorption,distribution and metabolism of drugs,and their extensive substrate specificity is one of the main factors leading to drug interactions.As substrates of transporters,biomarkers can reflect the function of transporter proteins through the changes of their own concentration,which is highly significant in pharmacology.The study of biomarkers helps to uncover transporter-mediated drug interactions.This article reviewed representative biomarkers of liver and kidney transporters,and discussed the significance,limitations and future directions of biomarkers in predicting transporter involved drug interactions.

关 键 词：生物标志物 转运体 药物-药物相互作用 

分 类 号：R969[医药卫生—药理学]