姜黄素固体分散体高效制备工艺优选  

Optimization of Efficient Preparation Technology of Curcumin Solid Dispersion

作　　者：任莉莉 陈静 李先君 屈炼石 程昆木 REN Li-li;CHEN Jing;LI Xian-jun;QU Lian-shi;CHENG Kun-mu(State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&ShaanxiInternational Joint Research Center for Oral Diseases&Department of Oral Histology and Pathology,School ofStomatology,the Fourth Military Medical University,Xi’an 710032,China;Research and Development Center forQinba Traditional Chinese Medicine Resources,School of Chemistry and Chemical Engineering,Ankang University,Ankang 725000,China)

机构地区：[1]军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病国际联合研究中心,第四军医大学口腔医院组织病理学教研室,陕西西安710032 [2]安康学院化学化工学院秦巴中药资源研发中心,陕西安康725000

出　　处：《食品与药品》2022年第4期300-303,共4页Food and Drug

基　　金：国家自然科学基金青年项目(编号:81801690);安康学院陕西高校第三批“青年杰出人才支持计划”配套项目(编号:2020AKJCRC01);安康学院高层次人才科研专项(编号:2018AYQDZR07);陕西省大学生创新创业训练计划项目(编号:S201911397008)。

摘　　要：目的优选高效制备姜黄素固体分散体的工艺。方法以PEG6000为载体材料,采用溶剂熔融法制备姜黄素固体分散体,通过正交试验优选制备工艺。采用X射线衍射图谱(XRD)及扫描电镜(SEM)表征固体分散体的性质。结果最优工艺为:姜黄素加入量20 mg,姜黄素:PEG6000=1:9,加入无水乙醇10 ml,熔融温度50℃。该条件制备的姜黄素固体分散体25 min内累积溶出度达93%。XRD图谱和SEM结果显示该固体分散体晶粒明显减少。结论该工艺过程简单有效,姜黄素固体分散体能显著提高姜黄素的溶出度。Objective To optimize the process for preparation of curcumin solid dispersion.Methods The process was optimized by orthogonal experiment,using PEG6000 as carrier material.The curcumin solid dispersion was prepared by solvent melting method.The solid dispersion was characterized by XRD and SEM.Results The optimal process was as follows:the amount of curcumin was 20 mg,the ratio of curcumin to PEG6000 was 1:9,the volume of anhydrous ethanol was 10 ml,and the melting temperature was 50℃.The cumulative dissolution of curcumin solid dispersion was 93%within 25 minutes.XRD and SEM results showed that the curcumin crystals decreased significantly in the solid dispersion.Conclusion The process is simple and feasible.Curcumin solid dispersion can effectively improve the dissolution of curcumin.

关 键 词：姜黄素 固体分散体 正交试验 溶出度 XRD SEM 

分 类 号：R943[医药卫生—药剂学]