2,6⁃二乙酰吡啶缩水杨酰腙衍生物的锰和镧配合物的合成、晶体结构及抗肿瘤活性  

Syntheses, Crystal Structures, and Antitumor Activities of Mn(Ⅱ)Complex and La(Ⅲ)Coordination Polymer with 2,6-Diacetylpyridine Salicylhydrazone Derivative

作　　者：祝典 张俊 张倩 梁舒琪 熊莺 姜亦凡 汪美芳 魏居媛[1] 范喜瑞 冯志君 ZHU Dian;ZHANG Jun;ZHANG Qian;LIANG Shu-Qi;XIONG Ying;JIANG Yi-Fan;WANG Mei-Fang;WEI Ju-Yuan;FAN Xi-Rui;FENG Zhi-Jun(School of Pharmacy,Wannan Medical College,Wuhu,Anhui 241002,China;Key Laboratory of Functionalized Molecular Solids,Ministry of Education,Anhui Normal University,Wuhu,Anhui 241002,China;The Key Laboratory of Antiinflammatory and Immuune Medicine,Ministry of Education,Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032,China;Department of Biochemistry,Wannan Medical College,Wuhu,Anhui 241002,China)

机构地区：[1]皖南医学院药学院,芜湖241002 [2]安徽师范大学功能分子固体教育部重点实验室,芜湖241002 [3]安徽医科大学抗炎免疫药物教育部重点实验室,安徽医科大学临床药理研究所,合肥230032 [4]皖南医学院生物化学教研室,芜湖241002

出　　处：《无机化学学报》2022年第8期1499-1511,共13页Chinese Journal of Inorganic Chemistry

基　　金：安徽省高校自然科学基金(No.KJ2019A0420,KJ2020A0619,KJ2021A0842);功能分子固体教育部重点实验室基金项目(No.FMS201904);国家级大学生创新创业训练计划项目(No.202010368031,202110368055,S202110368195,S202010368053);皖南医学院科研基金重点项目(No.WK2021Z16);抗炎免疫药物教育部重点实验室基金(No.KFJJ-2020-10);皖南医学院基层教研室示范项目(No.2019jyssf03)资助。

摘　　要：设计并合成了2,6-二乙酰吡啶缩水杨酰腙衍生物(2,6-((o-OH)C_(6)H_(4)C=ONHN=C(CH_(3)))_(2)C_(5)H_(3)N,H_(4)L)及其锰配合物[Mn(H_(2)L)(DMSO)_(2)](1)和镧配位聚合物{[La(H_(2)L)_(2)]_(2)[La_(2)(H_(2)L)_(2)(DMF)_(5)(H_(2)O)]·2DMF·2H_(2)O}_(n)(2)(DMSO=二甲基亚砜,DMF=N,N-二甲基甲酰胺)。配合物1和2的结构分别通过红外光谱、紫外可见光谱、元素分析进行了表征,并经单晶X射线衍射进一步确证。晶体结构分析表明配合物1属于正交晶系的P2_(1)2_(1)2_(1)空间群;配位聚合物2结晶于三斜晶系的P1空间群。用CCK-8法检测了1和2对体外结肠癌细胞HCT116和结直肠腺癌上皮细胞DLD-1的增殖抑制作用,结果表明1和2对HCT116和DLD-1细胞都有中等抑制作用:1的IC_(50)分别为(23.69±1.226)μmol·L^(-1)和(41.06±1.013)μmol·L^(-1);2的IC_(50)分别为(57.61±1.034)μmol·L^(-1)和(61.36±1.029)μmol·L^(-1)。Complex[MnH_(2)L(DMSO)_(2)](1)and coordination polymer{[La(H_(2)L)_(2)]_(2)[La_(2)(H_(2)L)_(2)(DMF)_(5)(H_(2)O)]·2DMF·2H_(2)O}_(n)(2)(DMSO=dimethyl sulfoxide,DMF=N,N-dimethylformamide)having 2,6-diacetylpyridine salicylhydrazone derivative(2,6-((o-OH)C_(6)H_(4)C=ONHN=C(CH_(3)))_(2)C_(5)H_(3)N,H_(4)L)as ligand were synthesized and characterized by IR,UV-Vis,elemental analysis and further by single-crystal X-ray diffraction.Complex 1 belongs to an orthorhombic crystal system with space group P2_(1)2_(1)2_(1),and coordination polymer 2 crystallizes in a triclinic crystal system with space group P1.Moreover,the in vitro antitumor activities of complex 1 and coordination polymer 2 were evaluated by CCK-8 assay in the colon(HCT116)and colorectal adenocarcinoma(DLD-1)cancer cell lines.And the resulting IC_(50) values were estimated to be as low as(23.69±1.226)μmol·L^(-1) and(41.06±1.013)μmol·L^(-1) for complex 1 or(57.61±1.034)μmol·L^(-1) and(61.36±1.029)μmol·L^(-1) for complex 2 against HCT116 and DLD-1 cells,respectively,proving cytotoxic activities of complex 1 and coordination polymer 2 against these two cancer cell lines.CCDC:2102080,1;2102079,2.

关 键 词：锰配合物 镧配位聚合物 2 6-二乙酰吡啶缩水杨酰腙 晶体结构 抗肿瘤活性 

分 类 号：O614.711[理学—无机化学] O614.331[理学—化学]