N⁃O螯合配体协同膦配体的银(Ⅰ)混配配合物的设计、结构和生物活性  

A Complex of Silver(Ⅰ)with N⁃O Chelating Agent and Phosphine Ligand:Design,Structures,and Biological Activity

作　　者：王仁舒 冯静 王远兰 欧阳晨枫 WANG Ren-Shu;FENG Jing;WANG Yuan-Lan;OUYANG Chen-Feng(School of Chemistry and Materials Engineering,Liupanshui Normal University,Liupanshui,Guizhou 553004,China;Guizhou Key Laboratory of Coal Clean Utilization,Liupanshu,Guizhou 553004,China;E.N.T.department,General Hospital of Zhongshan,Liupanshu,Guizhou 553000,China)

机构地区：[1]六盘水师范学院化学与材料工程学院,六盘水553004 [2]贵州省煤炭洁净利用重点实验室,六盘水553004 [3]六盘水市钟山人民医院耳鼻喉科,六盘水553000

出　　处：《无机化学学报》2022年第8期1609-1622,共14页Chinese Journal of Inorganic Chemistry

基　　金：贵州省普通高等学校青年科技人才成长项目(黔教合KY字[2020]123);贵州省煤炭洁净利用重点实验室(黔科合平台人才[2020]2001)资助。

摘　　要：合成了一种Ag(Ⅰ)配合物[Ag(Qina)(Tpp)_(2)]·1.5H_(2)O(Qina=2-喹啉羧酸根,Tpp=三苯基膦)。运用单晶X射线衍射、IR、NMR和粉末X射线衍射对配合物的结构进行了表征。配合物属于单斜晶系,C2/c空间群,晶胞参数:a=3.19590(13)nm,b=1.21096(4)nm,c=2.31974(7)nm,β=102.166(4)°,V=8.7760(5)nm^(3),Z=8。通过Hirshfeld表面分析,推导出配合物的超分子结构和分子间弱作用力。同时,通过DNA结合活性测试、抗菌活性和癌细胞体外毒活性测试,评价了配合物的生物活性。A new Ag(Ⅰ)complex,[Ag(Qina)(Tpp)_(2)]·1.5H_(2)O(Qina=2-quinolinecarboxylate,Tpp=triphenylphosphine),was synthesized and successfully obtained as a single crystal.The structure of the complex was characterized by single-crystal X-ray diffraction,IR,NMR,and powder X-ray diffraction.The results show that the complex belongs to monoclinic crystal system,C2/c space group,and the unit cell parameters are a=3.19590(13)nm,b=1.21096(4)nm,c=2.31974(7)nm,β=102.166(4)°,V=8.7760(5)nm^(3),and Z=8.The supramolecular structures and weak intermolecular force of the complex were deduced by Hirshfeld surface analysis.Meanwhile,the biological activities of the complex were tested by evaluating DNA-binding efficacy,antibacterial activity,and in vitro toxic activity of cancer cells.CCDC:2142361.

关 键 词：银(Ⅰ)配合物 Hirshfeld表面电荷分析 晶体结构 生物活性 

分 类 号：O614.122[理学—无机化学]