消眩止晕片糖衣片改薄膜衣片包衣工艺研究  

Study on the Coating Technology of XiaoXuan ZhiYun Tablet from Sugar-Coated Tablet to Film-Coated Tablet

作　　者：谭劼 林泉松 夏晟 周在富 唐秋菊 Tan Jie;Lin Quansong;Xia Sheng;Zhou Zaifu;Tang Qiuju(Chongqing Kerui Pharmaceutical(Group)Co.,Ltd.,Chongqing 400060,China;Chongqing Vocational College of Chemical Industry,Chongqing 401220,China)

机构地区：[1]重庆科瑞制药(集团)有限公司,重庆400060 [2]重庆化工职业学院,重庆401220

出　　处：《山东化工》2022年第12期32-34,37,共4页Shandong Chemical Industry

摘　　要：目的:为适应临床使用需求,探索消眩止晕片由糖衣改为薄膜衣的生产工艺。方法:通过稳定性试验,筛选合适的包衣材料生产厂家;设计正交试验,确定薄膜包衣的最佳工艺参数。结果:影响薄膜衣片崩解时限和包衣合格率的最大因素为包衣液浓度,其次为包衣液喷速,进风温度对试验结果影响较小,确定薄膜包衣最佳工艺参数为包衣液浓度16%,包衣液喷速160 g/min,进风温度55℃。结论:此工艺稳定,可用于消眩止晕片工业生产。Objective:In order to meet the needs of clinical use,to explore the production technology of XiaoXuan ZhiYun tablet from sugar coating to film coating.Method:Through the stability test,select the suitable coating material manufacturers;The orthogonal experiment was designed to determine the optimum technological parameters of film coating.Results:The concentration of coating solution is the most important factor that affects the disintegration time and coating qualification rate of film-coated tablets,next is the coating liquid spray speed,the temperature of inlet air has little influence on the test results,the optimum technological parameters of film coating were determined to be the concentration of coating solution 16%,spraying speed of coating solution 160 G/min and inlet air temperature 55℃.Conclusion:The process is stable and can be used in the industrial production of XiaoXuan ZhiYun tablets.

关 键 词：消眩止晕片 薄膜包衣 正交试验 

分 类 号：TQ460[化学工程—制药化工]