2型糖尿病患者肠道菌落水平与血脂代谢水平和胰岛素抵抗指数的相关性  

Correlations of intestinal flora levels with blood lipid metabolism levels and insulin resistance index in patients with type 2 diabetes mellitus

作　　者：徐敏 党少华[1] 辛宁[1] XU Min;DANG Shaohua;XIN Ning(The Third People’s Hospital of Zhengzhou,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州市第三人民医院,河南郑州450000

出　　处：《中国民康医学》2022年第13期141-143,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析2型糖尿病(T2DM)患者肠道菌落水平与血脂代谢水平和胰岛素抵抗指数的相关性。方法:选取2020年1-12月该院收治的126例T2DM患者作为观察组,选取同期于该院进行常规体检的100名健康者作为对照组,进行病例对照研究。根据肠道菌落情况又将观察组分为肠道菌落异常组(n=52,粪便培养中计算B/E值<1)和肠道菌落正常组(n=74,B/E值≥1)。测定并比较三组肠道菌落水平、血脂代谢指标[三酰甘油(TC)、总胆固醇(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平和胰岛素抵抗指数水平,并采用Pearson相关性分析,分析T2DM患者肠道菌落水平与血脂代谢指标水平和胰岛素抵抗指数的相关性。结果:肠道菌落异常组拟杆菌水平低于肠道菌落正常组和对照组,且肠道菌落正常组低于对照组;肠道菌落异常组肠球菌、柔嫩梭菌水平高于肠道菌落正常组和对照组,且肠道菌落正常组高于对照组,差异均有统计学意义(P<0.05)。肠道菌落异常组胰岛素抵抗指数水平、TC水平、TG水平、LDL-C水平均高于肠道菌落正常组和对照组,且肠道菌落正常组高于对照组,差异均有统计学意义(P<0.05);肠道菌落异常组HDL-C水平低于肠道菌落正常组和对照组,且肠道菌落正常组低于对照组,差异均有统计学意义(P<0.05)。Pearson相关性分析结果显示,T2DM患者肠道拟杆菌水平与胰岛素抵抗指数呈负相关(r<0,P<0.05);T2DM患者肠道柔嫩梭菌水平与HDL-C水平呈负相关(r<0,P<0.05),与胰岛素抵抗指数呈正相关(r>0,P<0.05);T2DM患者肠道肠球菌水平与TG水平呈正相关(r>0,P<0.05),与HDL-C水平呈负相关(r<0,P<0.05)。结论:T2DM患者肠道菌落水平异常与血脂代谢水平和胰岛素抵抗指数存在相关性。Objective: To observe correlations of intestinal flora levels with blood lipid metabolism levels and insulin resistance index in patients with type 2 diabetes mellitus(T2DM). Methods: 126 T2DM patients admitted to our hospital from January to December 2020 were selected as observation group, and 100 healthy individuals who underwent routine physical examination in our hospital during the same period were selected as control group.They were included in a case-control study. According to the intestinal flora conditions, the observation group was subdivided into abnormal intestinal flora group(n=52, B/E value calculated in fecal culture <1) and normal intestinal flora group(n=74, B/E value ≥ 1). The levels of intestinal flora, the blood lipid metabolism indexes levels [triacylglycerol(TC), total cholesterol(TG), high-density lipoprotein cholesterol(HDL-C), and low-density lipoprotein cholesterol(LDL-C)], and the insulin resistance index levels were measured and compared among the three groups. Pearson correlation analysis was used to analyze the correlations among the intestinal flora levels and the blood lipid metabolism levels and the insulin resistance index in the patients with T2DM. Results:The level of Bacteroides in the abnormal intestinal flora group was lower than those in the normal intestinal flora group and the control group, and that of the normal intestinal flora group was lower than that of the control group;the levels of Enterococcus and Clostridium leptum in the abnormal intestinal flora group was higher than those in the normal intestinal flora group and the control group, and that of the normal intestinal flora group was higher than that of the control group;and the differences were statistically significant(P<0.05). The levels of insulin resistance index, TC, TG and LDL-C in the abnormal intestinal flora group were higher than those in the normal intestinal flora group and the control group, those of the normal intestinal flora group were higher than those of the control group, and the differen

关 键 词：2型糖尿病 肠道菌落失常 血脂代谢 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]