血小板抗体表达和输血次数对血液病患者血小板输注疗效的影响  

Effects of platelet antibody expression and number of blood transfusion on platelet transfusion efficacy in patients with hematological diseases

作　　者：黄秀凤[1] 颜沛云[1] 江燕 庄大造 黄清灏 HUANG Xiufeng;YAN Peiyun;JIANG Yan;ZHUANG Dazao;HUANG Qinghao(Department of Blood Transfusion of the People’s Hospital of Gaozhou,Maoming 525200 Guangdong,China)

机构地区：[1]高州市人民医院输血科,广东茂名525200

出　　处：《中国民康医学》2022年第13期144-146,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨血小板抗体表达和输血次数对血液病患者血小板输注疗效的影响。方法:回顾性分析2020年6月至2021年6月在该院接受血小板输注治疗的322例血液病患者的临床资料,患者至少输血3次,统计患者血小板输注无效(PTR)发生率,并比较不同血小板抗体表达情况及输血次数患者的PTR发生率。结果:322例血液病患者PTR发生率为41.61%(134/322),血小板抗体阴性156例,阳性166例。血小板抗体阳性患者PTR发生率显著高于阴性患者,差异有统计学意义(P<0.05);累计输注次数>6次患者PTR发生率、血小板抗体阳性率显著高于累计输注次数3~6次患者,差异有统计学意义(P<0.05)。结论:血小板抗体阳性及输血次数会影响血小板输注疗效,在对血液病患者进行血小板输注时应进行血小板抗体筛查,采取有效措施,降低PTR发生率。Objective: To explore effects of platelet antibody expression and number of blood transfusion on platelet transfusion efficacy in patients with hematological diseases. Methods: 322 patients with hematological diseases who received platelet transfusion in this hospital from June 2020 to June 2021 were included in the study and were retrospectively analyzed. These patients received at least 3 blood transfusions. The incidence of platelet transfusion refractory(PTR) in these patients was statistically analyzed. Further, the incidences of PTR in the patients with different platelet antibody expressions and number of blood transfusion were compared. Results: The incidence of PTR was 41.61%(134/322) in the 322 patients with hematological diseases, among which, 156 were negative for platelet antibody and 166 were positive. The incidence of PTR in the patients with positive platelet antibody was significantly higher than that in the patients with negative platelet antibody, and the difference was statistically significant(P<0.05). Further, the incidence of PTR and the positive rate of platelet antibody in patients with cumulative number of blood transfusion >6were significantly higher than those in the patients with number of blood transfusion of 3-6, and the differences were statistically significant(P<0.05).Conclusions: The positive platelet antibody and the number of blood transfusions will affect the efficacy of platelet transfusion. Therefore, the platelet antibody screening should be performed when platelet transfusions are given to the patients with hematological diseases, and the effective measures should be taken to reduce the incidence of PTR.

关 键 词：血小板抗体 血液病 血小板输注 输血次数 血小板输注无效 

分 类 号：R457.1[医药卫生—治疗学]