Mapping big brains at subcellular resolution in the era of big data in zoology  

作　　者：Yan Shen Lu-Feng Ding Chao-Yu Yang Fang Xu Pak-Ming Lau Guo-Qiang Bi 

机构地区：[1]Interdisciplinary Center for Brain Information,Brain Cognition and Brain Disease Institute,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,Guangdong 518000,China [2]Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui 230001,China [3]Institute of Artificial Intelligence,Hefei Comprehensive National Science Center,Hefei,Anhui 230001,China

出　　处：《Zoological Research》2022年第4期597-599,共3页动物学研究（英文）

基　　金：supported by the Ministry of Science and Technology of China(2022ZD0205203)。

摘　　要：Connectome-scale structural mapping is fundamental for understanding the underlying mechanisms of brain cognition and brain disease pathogenesis.By combining rapidly developing three-dimensional(3D)imaging techniques and big data analysis methods,researchers are working on mesoscale mapping of mammalian brains at an accelerated pace.Here,we briefly describe existing brain-wide imaging strategies,especially our recently established primateoptimized pipeline capable of pan-brain neuronal connectivity mapping at subcellular resolution,and further discuss their vast application prospects in the big data era of zoology.

关 键 词：MAPPING RESOLUTION MAPPING 

分 类 号：Q42[生物学—神经生物学]