中医药调控细胞自噬治疗脊髓损伤的方法、技术及未来  

Methods,technologies and future of Chinese medicine modulation of cellular autophagy in the treatment of spinal cord injury

作　　者：王雅欣 林一璨 郭伊诺 张博 马玉滢 贺小平 Wang Yaxin;Lin Yican;Guo Yinuo;Zhang Bo;Ma Yuying;He Xiaoping(Hebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Disease,Hebei University of Chinese Medicine,Shijiazhuang 050091,Hebei Province,China)

机构地区：[1]河北中医学院,河北省心脑血管病中医药防治研究重点实验室,河北省石家庄市050091

出　　处：《中国组织工程研究》2023年第13期2116-2123,共8页Chinese Journal of Tissue Engineering Research

基　　金：河北省中医药管理局资助项目(2022105),项目负责人:贺小平;河北省卫生健康委员会(20221046),项目负责人:贺小平;燕赵医学研究专项(YZYX2021006),项目负责人:贺小平。

摘　　要：背景:中医疗法如中医药及针灸取穴通过调节自噬在脊髓损伤的治疗中显示出良好效果,并逐渐在脊髓损伤的治疗中占据重要地位。目的:总结中医药调控细胞自噬治疗脊髓损伤的研究进展。方法:以“spinal cord injury,autophagy,traditional Chinese medicine,signal”为检索词检索PubMed数据库,以“脊髓损伤、自噬、中医、信号通路”为检索词检索中国知网数据库,检索时限为2014年1月至2022年1月,排除与文章研究目的无关及重复性文章,纳入符合标准的72篇文献进行综述。结果与结论:①从脊髓损伤的中医机制及治疗来说,脊髓损伤早期一系列症状常是由于督脉受损引起,与受损后产生气滞血瘀密切相关,因此可以进行活血化瘀和督脉论治。②自噬的中医理论主要联系“阴阳”和“气血”,并且根据不同疾病主要围绕脾、肝、肾进行脏腑辨证。③大量实验研究表明,中医药及针灸可以调控细胞自噬蛋白、信号通路的表达且可以有效抑制脊髓损伤后的炎症反应,有利于减轻脊髓损伤后炎症反应并保护脊髓神经元,改善损伤后运动及神经元的受损情况。④中医药调控细胞自噬治疗脊髓损伤是目前研究热点,但大部分研究停留在理论阶段,有些中医疗法的具体作用机制尚未明确。⑤中医药领域对自噬的研究与西医相比较少,其中通过调控自噬治疗脊髓损伤研究的科研力度尤其应该加强。⑥未来希望研究者们对典型中医药进行配伍,联合针灸、西药治疗,进行针对性实验研究,以期找到治疗脊髓损伤更有效的中医疗法及中西结合疗法。BACKGROUND:Traditional Chinese medicine therapies such as traditional Chinese medicine and acupuncture have shown good effects on the treatment of spinal cord injury by modulating autophagy,and gradually occupy an important position in the treatment of spinal cord injury.OBJECTIVE:To summarize the research progress addressing the regulation of cellular autophagy for treating spinal cord injury using Chinese medicine.METHODS:The PubMed database was searched with“spinal cord injury,autophagy,traditional Chinese medicine,signal”as the main search terms.CNKI database was searched with“spinal cord injury,autophagy,traditional Chinese medicine,signal pathway”as the main search terms.The search period was from January 2014 to January 2022.Irrelevant and repetitive articles were excluded and 72 articles that met the criteria were included in the review.RESULTS AND CONCLUSION:(1)Regarding the traditional Chinese medicine mechanism and treatment of spinal cord injury,a series of symptoms in the early stage of spinal cord injury are often caused by the damage of the Directing Vessel,which is strongly associated with the production of qi stagnation and blood stasis after the damage,so the treatment can be carried out to activate blood circulation and remove blood stasis and the Directing Vessel.(2)The traditional Chinese medicine theory of autophagy is mainly associated with“yin and yang”and“qi and blood”.According to different diseases,the identification of internal organs is mainly based on the spleen,liver,and kidney.(3)Numerous experimental studies have confirmed that traditional Chinese medicine and acupuncture can modulate the expression of cellular autophagy proteins and signaling pathways and can effectively suppress the inflammatory response after spinal cord injury,which is conducive to reducing the inflammatory response after spinal cord injury and protecting spinal cord neurons,and improving motor and neuronal damage after injury.(4)Autophagy regulation by traditional Chinese medicine for spinal c

关 键 词：细胞自噬 脊髓损伤 信号通路 中医药 针灸 神经 机制 阴阳 气血 综述 

分 类 号：R452[医药卫生—治疗学] R363[医药卫生—临床医学] R228