喜疗妥预防外周静脉炎效果的系统评价  

Systematic review of hirudoid for the prevention of peripheral phlebitis

作　　者：陈亚丹[1] 代田[1] 陈丽娜[1] 尹沙 罗芳[1] 张雪好 CHEN Yadan;DAI Tian;CHEN Li′na;YIN Sha;LUO Fang;ZHANG Xuehao(The First Affiliated Hospital of Xiamen University,Fujian 364000 China)

机构地区：[1]厦门大学附属第一医院,福建364000

出　　处：《循证护理》2022年第15期1997-2004,2031,共9页Chinese Evidence-Based Nursing

摘　　要：目的:系统评价喜疗妥预防外周静脉炎的效果。方法:计算机检索万方数据库、中国知网(CNKI)、the Cochrane Library,PubMed,EMbase,BMJ等数据库中关于喜疗妥预防外周静脉炎的随机对照试验(RCT),检索时间为建库至2020年12月1日,筛选文献并提取资料,对符合标准的随机对照试验采用Cochrane随机对照试验风险偏倚评价工具评价文献质量,应用RevMan 5.3进行Meta分析,当异质性较大时采用随机效应模型,反之则采用固定效应模式进行分析。结果:共纳入10篇文献,13项随机对照试验,涉及944例病人,Meta分析结果显示:与常规护理相比,喜疗妥能有效预防静脉炎的发生[RR=0.24,95%CI(0.15,0.37),P<0.00001]及降低静脉炎的严重程度[RR=0.18,95%CI(0.07,0.45),P=0.0003]。结论:现有证据表明,喜疗妥相较于常规护理能有效预防静脉炎的发生,并降低静脉炎的严重程度,但是由于研究之间的异质性及纳入研究的质量不等,该证据在临床应用过程中仍需谨慎实施。Objective:To systematically evaluate the efficacy of hirudoid in the prevention of peripheral phlebitis.Methods:Randomized controlled trials(RCT)on the prevention of peripheral phlebitis with hirudoid were retrieved from WanFang Database,CNKI,the Cochrane Library,PubMed,EMbase,BMJ.The retrieval time was from the establishment of the database to December 1,2020.Artides were screened and data were extracted.The Cochrane RCT risk bias assessment tool was used to evaluate the quality of randomized controlled trials that met the criteria,and RevMan 5.3 was used for Meta-analysis.When the heterogeneity was large,the random-effects model was used,otherwise,the fixed-effects model was used for analysis.Results:A total of 10 articles and 13 randomized controlled trials involving 944 patients receiving peripheral intravenous fluids were included.The results of Meta-analysis showed that compared with conventional nursing,hirudoid could effectively prevent the occurrence of phlebitis[RR=0.24,95%CI(0.15,0.37),P<0.00001]and reduce the severity of phlebitis[RR=0.18,95%CI(0.07,0.45),P=0.0003].Conclusions:Existing evidence shows that hirudoid can effectively prevent the occurrence of phlebitis and reduce the severity of phlebitis compared with routine nursing.However,due to the heterogeneity between studies and the unequal quality of included studies,this evidence still needs to be implemented with caution in the clinical application process.

关 键 词：静脉炎 外周静脉 喜疗妥 系统评价 循证护理 

分 类 号：R472[医药卫生—护理学]