健脾祛瘀法治疗Ⅲ/Ⅳ期胃癌疗效观察  

Observation on Clinical Effects of Invigorating-spleen Removing-stasis Method in the Treatment of Stage Ⅲ/Ⅳ Gastric Cancer

作　　者：贾英丽 徐悦泽 刘坤 王英丽 吴心力 JIA Yingli;XU Yueze;LIU Kun;WANG Yingli;WU Xinli(Heilongjiang Provincial Academy of Traditional Chinese Medicine,Harbin 150036,China)

机构地区：[1]黑龙江省中医药科学院,黑龙江哈尔滨150036

出　　处：《西部中医药》2022年第7期58-60,共3页Western Journal of Traditional Chinese Medicine

基　　金：黑龙江省中医药科研项目(ZHY18-046)。

摘　　要：目的:观察健脾祛瘀法治疗Ⅲ/Ⅳ期脾胃虚弱、血瘀内阻证胃癌的临床疗效。方法:将48例胃癌Ⅲ/Ⅳ期脾胃虚弱、血瘀内阻证患者按随机数字表法分为观察组和对照组各24例,观察组口服健脾祛瘀方汤剂,每日1剂,对照组口服平消胶囊,每次4粒,每日3次,1个月1个疗程,连服2个疗程后观察两组患者治疗前后中医症状积分、卡劳夫斯基(Karnofsky)行为状况评分与肿瘤标志物改善情况。结果:治疗后观察组患者中医症状改善均优于治疗前及对照组治疗后,差异有统计学意义(P<0.05);体力状况改善优于对照组,差异有统计学意义(P<0.05);治疗后观察组肿瘤标志物癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原199(carbohydrate antigen-199,CA199)水平低于治疗前及对照组治疗后(P<0.05),糖类抗原125(carbohydrate antigen-125,CA125)低于治疗前(P<0.05),但与对照组治疗后比较差异无统计学意义(P>0.05)。结论:健脾祛瘀方能改善Ⅲ/Ⅳ期脾胃虚弱、血瘀内阻证胃癌患者的中医症状及体力状况,抑制肿瘤标志物水平,效果优于平消胶囊。Objective:To observe clinical effects of invigorating-spleen removing-stasis method in treating stage Ⅲ/Ⅳ gastric cancer of spleen and stomach deficiency and blood stasis internal obstruction pattern.Methods:All 48 patients were allocated to the observation group and the control group according to random number table method,with 24 cases in each group,the observation group took invigorating-spleen removing-stasis decoction,one dose each day,and the control group received Pingxiao capsules orally,four pills each time,three times each day,one month was one course of the treatment,after two courses of the treatment,to observe the improvements of TCM syndrome scores,Karnofsky behavioral state scores and tumor markers before and after the intervention between both groups.Results:After the treatment,the improvements of TCM symptoms the improve ments of physical conditions of the observation group were better than these before treating,and these of the control group after treatment,and the difference had statistical meaning(P<0.05);were superior to these of the control group,and the difference had statistical meaning(P<0.05);after the treatment,the levels of tumor markers CEA and CA199 of the observation group were lower than these before treatment,and these of the control group after treatment(P<0.05),the level of CA125 was lower than that before treatment(P<0.05),the difference had no statistical meaning when the observation group was compared with the control group after treatment(P>0.05).Conclusion:Invigorating-spleen removing-stasis prescription could improve TCM symptoms and physical conditions in the patients of stage Ⅲ/Ⅳ gastric cancer of spleen and stomach deficiency and blood stasis internal obstruction pattern,inhibit the levels of tumor markers,and its effects superior to these of Pingxiao capsules.

关 键 词：胃癌 Ⅲ/Ⅳ期 平消胶囊 健脾祛瘀法 临床观察 

分 类 号：R256.3[医药卫生—中医内科学]