平喘汤联合沙丁胺醇对哮喘性支气管炎患儿Rrs SO、Crs SO水平的影响  

Effects of Pingchuan Tang Combined with Salbutamol on the Levels of Rrs SO and Crs SO in Children with Asthmatic Bronchitis

作　　者：綦梅伶 王静[1] 邵茜彤 QI Meiling;WANG Jing;SHAO Xitong(Pediatric Department,Jining Hospital of TCM,Jining 272000,China)

机构地区：[1]济宁市中医院儿科,山东济宁272000

出　　处：《西部中医药》2022年第7期79-82,共4页Western Journal of Traditional Chinese Medicine

摘　　要：目的:探讨平喘汤联合沙丁胺醇对哮喘性支气管炎患儿呼吸系统阻力(respiratory system resistance,Rrs SO)、呼吸系统静态顺应性(circulatory system resistance,Crs SO)水平的影响。方法:将哮喘性支气管炎患儿84例采用随机数字表法分为联合组和对照组各42例。在常规治疗基础上,对照组患儿予沙丁胺醇治疗,联合组患儿予平喘汤联合沙丁胺醇治疗。治疗7天后分析两组患儿临床疗效、中医证候消失时间及住院时间、肺功能指标、血清生化指标。结果:联合组总有效率为95.24%,高于对照组的80.95%,差异有统计学意义(P<0.05)。联合组喘息、咳嗽、哮鸣音、肺部啰音消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后两组患者Rrs SO水平较治疗前降低,Crs SO水平均较治疗前升高,且联合组降低/升高更显著(P<0.05)。治疗后两组患者血清生化指标[免疫球蛋白E(immuno globulin E,IgE)、白细胞介素6(interleukin-6,IL-6)及肿瘤坏死因子α(tumor necrosis factorα,TNF-α)]水平较治疗前降低,且联合组降低更显著(P<0.05)。结论:在常规治疗的基础上,平喘汤联合沙丁胺醇可快速缓解哮喘性支气管炎患儿临床症状,改善肺功能及机体炎症状态,疗效优于常规治疗联合沙丁胺醇。Objective:To explore the effects of Pingchuan Tang jointed with salbutamol on Rrs SO and Crs SO in children with asthmatic bronchitis.Methods:All 84 children were allocated to the combination group and the control group by random number table method.Based on conventional therapy,the control group was treated by salbutamol,and the combination group by Pingchuan Tang jointed with salbutamol.After seven days of treatment,to analyze clinical effects,the disappearing time of TCM syndromes,hospital stay,the indexes of pulmonary function and serum biochemical indexes between both groups.Results:Total effective rate of the combination group was 95.24%,higher than 80.95%of the control group,and the difference had statistical meaning(P<0.05).The disappearing time asthma,cough,wheezing rale and lung rale and hospital stay of the combination group were shorter than these of the control group,and the difference had statistical meaning(P<0.05).After the treatment,the levels of Rrs SO in both groups lowered compared with these before treatment,the levels of Crs SO increased than these before treatment,the decrease or the increase of the combination group was more noticeable(P<0.05).After the treatment,the levels of biochemical indicators[IgE,IL-6 and TNF-α]in both groupswere lower than these before treatment,and the reduction of the combination groupwasmore obvious(P<0.05).Conclusion:Pingchuan Tang in combination with salbutamol could rapidly relieve clinical symptoms,improve pulmonary function and inflammatory state of organism,and its clinical effects are better than these of conventional therapy and salbutamol.

关 键 词：支气管炎 哮喘 呼吸系统阻力 呼吸系统静态顺应性 平喘汤 沙丁胺醇 儿童 

分 类 号：R256.12[医药卫生—中医内科学]