沙丁胺醇气雾剂联合羧甲司坦片治疗AECOPD患者的临床效果  

Clinical effect of salbutamol aerosol combined with carbocisteine tablets in the treatment of patients with AECOPD

作　　者：汪娟 靳攀 Wang Juan;Jin Pan(Taihe Hospital of Anhui University of Traditional Chinese Medicine,Fuyang 236699,China)

机构地区：[1]安徽中医药大学附属太和中医院,阜阳236699

出　　处：《湖南师范大学学报（医学版）》2022年第3期13-16,共4页Journal of Hunan Normal University(Medical Sciences)

基　　金：安徽省自然科学基金项目(1808085MH303)。

摘　　要：目的:研究沙丁胺醇吸入气雾剂联合羧甲司坦片对慢性阻塞性肺疾病急性加重期(AECOPD)患者的治疗效果.方法:选取2019年12月~2021年12月安徽中医药大学附属太和中医院住院的80例AECOPD患者,采用数字奇偶法分为对照组(给予沙丁胺醇吸入气雾剂治疗,40例)和观察组(给予沙丁胺醇吸入气雾剂+羧甲司坦片治疗,40例).对比两组患者有效率、COPD评分(CAT)评分、肺功能及血清炎症因子水平.结果:观察组治疗总有效率高于对照组.与治疗前相比,对照组和观察组患者CAT评分均降低,且观察组CAT评分低于对照组.观察组治疗后患者FEV1、FVC及FEV1/FVC比值均高于对照组.治疗后观察组TNF-α、IL-1β、IL-6水平均低于对照组.结论:沙丁胺醇吸入气雾剂、羧甲司坦片两种药物联合用于治疗AECOPD患者的疗效优于单用沙丁胺醇吸入气雾剂,且能够降低炎症因子水平.Objective To study the therapeutic effect of salbutamol inhalation aerosol combined with carbocisteine tablets in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods From December 2019 to December 2021,80 patients with AECOPD who were hospitalized in Taihe Hospital Affiliated to Anhui University of Tradi-tional Chinese Medicine were selected and divided into control group(treated with salbutamol inhalation aerosol,40 cases)and observation group by digital parity method.group(40 patients were treated with salbutamol inhalation aerosol+carbocisteine tablets).The effective rate,COPD score(CAT)score,pulmonary function and serum inflammatory factor levels were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group.After treatment,the CAT scores of the control group and the observation group were decreased,and the CAT score of the observation group was lower.After treatment,FEV1,FVC and FEV1/FVC ratio in the observation group was higher than that in the control group.After treatment,the levels of TNF-α,IL-1βand IL-6 in observation group were lower.Conclusion Salb-utamol inhalation inhalation aerosol and carbocisteine tablets are more effective than salbutamol inhalation aerosol alone in the treatment of patients with AECOPD,and can reduce the level of inflammatory factors.

关 键 词：沙丁胺醇 羧甲司坦 慢性阻塞性肺疾病 急性加重期 炎症反应 

分 类 号：R563[医药卫生—呼吸系统]