结核分枝杆菌感染时巨噬细胞中线粒体结构与功能改变的研究进展  

Advances in structural and functional changes of mitochondria by Mycobacterium tuberculosis infected macrophages

作　　者：郎琴 许瑞[1] 杜先智[1] Lang Qin;Xu Rui;Du Xianzhi(Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400064,China)

机构地区：[1]重庆医科大学附属第二医院呼吸与危重症医学科,重庆400064

出　　处：《国际呼吸杂志》2022年第13期979-983,共5页International Journal of Respiration

基　　金：重庆市自然科学基金面上项目 (cstc2021jcyj-msxmX0216)。

摘　　要：2019年全球估计有结核病患者1000万,结核病仍然是单一感染性病原体导致的最常见死因。巨噬细胞作为抗结核分枝杆菌(MTB)的第一道免疫防线,它既可通过多种机制清除MTB,也可为MTB的生长提供有利场所。在MTB感染巨噬细胞时,线粒体结构与功能发生改变,进一步影响巨噬细胞存活及MTB生长。本文就MTB感染巨噬细胞时线粒体结构与功能改变研究进展进行阐述。There are estimated to be 10.0 million tuberculosis patients globally in 2019.Tuberculosis remaines the most common cause of death from a single pathogen.As the first-line responders against mycobacterium tuberculosis(MTB),macrophages can not only eliminate MTB by multi-mechanism,but also provide a place for favorable growth of MTB.MTB-infected macrophages initiate structure and function changes of mitochondria to further affect its survival and MTB growth.This article reviews the advances in the changes of mitochondrial structure and function by MTB-infected macrophages.

关 键 词：结核分枝杆菌 巨噬细胞 线粒体 

分 类 号：R52[医药卫生—内科学]