骨形态发生蛋白-9在骨再生中的应用进展  

Application progress of bone morphogenetic protein 9 in bone regeneration

作　　者：张俊河[1] 马静 梁卓 樊振林 任文杰 Zhang Junhe;Ma Jing;Liang Zhuo;Fan Zhenlin;Ren Wenjie(Institutes of Health Central Plains,Xinxiang Medical University,Xinxiang 453003,China)

机构地区：[1]新乡医学院健康中原研究院,453003

出　　处：《中华实验外科杂志》2022年第6期1202-1204,共3页Chinese Journal of Experimental Surgery

基　　金：国家重点研发计划课题(2018YFC1105804)。

摘　　要：在骨组织工程中, 生长因子作为重要的信号分子, 为改善骨再生提供了新希望。骨形态发生蛋白(BMP)-9, 又名生长分化因子2(GDF2), 是BMP家族中最新发现和极具成骨潜力的骨形成生长因子, 已被广泛应用于骨组织工程。BMP触发的Smad细胞信号通路通常被Noggin抑制, 而BMP-9对Noggin具有抗性, 进一步促进骨祖细胞向前成骨细胞分化。本综述拟讨论BMP-9在成骨中的信号转导方式以及在骨组织工程中用于基因治疗的进展, 并分析BMP-9在骨损伤修复方面中的应用和发展方向。In bone tissue engineering,as important signaling molecules,growth factors provide new hope for improving bone regeneration.Bone morphogenetic protein-9(BMP-9),also known as growth differentiation factor 2(GDF2),is the latest discovery in the BMP family and a bone-forming growth factor with great osteogenic potential,which has been widely used in bone tissue engineering.The Smad cell signaling pathway triggered by BMP is usually inhibited by Noggin,and BMP-9 is resistant to Noggin,which further promotes the differentiation of osteoprogenitor cells into pre-osteoblasts.This review discusses the signal transduction modes of BMP-9 in osteogenesis and the progress of gene therapy in bone tissue engineering,analyzes the application and development of BMP-9 in bone injury repair.

关 键 词：骨形态发生蛋白-9 骨组织工程 基因治疗 

分 类 号：R68[医药卫生—骨科学]