胆乐胶囊联合茴三硫治疗慢性胆囊炎的临床研究  

Clinical study of Danle Capsules combined with anethol trithione in treatment of chronic cholecystitis

作　　者：董家山 乔磊 段志方 李亚青[2] DONG Jia-shan;QIAO Lei;DUAN Zhi-fang;LI Ya-qing(Department of General Surgery,the People’s Hospital of Hebi,Hebi 458000,China;Department of General Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]鹤壁市人民医院综合外科,河南鹤壁458000 [2]郑州大学第一附属医院综合外科,河南郑州450052

出　　处：《现代药物与临床》2022年第6期1279-1282,共4页Drugs & Clinic

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190004)。

摘　　要：目的探讨胆乐胶囊联合茴三硫片治疗慢性胆囊炎的临床疗效。方法选取2019年4月—2021年7月在鹤壁市人民医院就诊的90例慢性胆囊炎患者作为研究对象,根据随机数字表法将所有患者分为对照组和治疗组,每组各有45例。对照组口服茴三硫片,25 mg/次,1次/d。治疗组在对照组基础上口服胆乐胶囊,1.2 g/次,3次/d。两组患者连续治疗4周。观察两组临床疗效,比较两组的胆囊收缩功能、胆囊壁厚度、视觉模拟评分法(VAS)评分以及血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、瘦素(Lep)水平。结果治疗后,治疗组总有效率(95.56%)高于对照组(82.22%),组间比较有显著差异(P<0.05)。治疗后,两组的胆囊收缩功能明显高于治疗前,胆囊壁厚度明显低于治疗前(P<0.05);治疗组的胆囊收缩功能比对照组高,胆囊壁厚度比对照组低(P<0.05)。治疗后,两组VAS评分明显低于治疗前(P<0.05),且治疗组的VAS评分比对照组低(P<0.05)。治疗后,两组的血清CRP、IL-6、Lep水平显著降低(P<0.05);治疗后治疗组的血清CRP、IL-6、Lep比对照组低(P<0.05)。结论胆乐胶囊联合茴三硫片治疗慢性胆囊炎的疗效确切,能改善胆囊症状,减轻腹痛程度,降低炎症反应,治疗安全性良好。Objective To investigate the clinical efficacy of Danle Capsules combined with Anethol Trithione Tablets in treatment of chronic cholecystitis.Methods Patients(84 cases)with chronic cholecystitis in the People’s Hospital of Hebi from April 2019 to July 2021 were randomly divided into control and treatment groups,and each group had 45 cases.Patients in the control group were po administered with Anethol Trithione Tablets,25 mg/time,once daily.Patients in the treatment group were po administered with Danle Capsules on the basis of the control group,1.2 g/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies were evaluated,and gallbladder contraction function,gallbladder wall thickness,VAS scores,and serum levels of CRP,IL-6,and Lep in two groups were compared.Results After treatment,the total effective rate of the treatment group(95.56%)was higher than that of the control group(82.22%)(P<0.05).After treatment,the gallbladder contraction function in two groups was significantly higher than before treatment,but the gallbladder wall thickness in two groups was significantly lower than before treatment(P<0.05).The gallbladder contraction function in the treatment group was higher than that in the control group,but the thickness of gallbladder wall in the treatment group was lower than that in the control group(P<0.05).After treatment,the VAS score of two groups was significantly lower than that before treatment(P<0.05),and the VAS score of the treatment group was lower than that of the control group(P<0.05).After treatment,the serum levels of CRP,IL-6,and Lep in two groups were significantly decreased(P<0.05).After treatment,the serum levels of CRP,IL-6,and Lep in the treatment group were lower than those in the control group(P<0.05).Conclusion Danle Capsules combined with Anethol Trithione Tablets is effective in the treatment of chronic cholecystitis,can improve gallbladder symptoms,reduce the degree of abdominal pain,reduce inflammatory reaction,wtih good sa

关 键 词：胆乐胶囊 茴三硫片 慢性胆囊炎 胆囊收缩功能 VAS评分 C反应蛋白 瘦素 

分 类 号：R975[医药卫生—药品]