复方氨肽素片联合卤米松乳膏治疗寻常型银屑病的临床研究  

Clinical study on Compound Amino-polypeptide Tablets combined with Halometasone Cream in treatment of psoriasis vulgaris

作　　者：李丹[1] 孟静[1] 韩传恩[1] LI Dan;MENG Jing;HAN Chuan-en(Department of Dermatology,Shangqiu First People’s Hospital,Shangqiu 476100,China)

机构地区：[1]商丘市第一人民医院皮肤科,河南商丘476100

出　　处：《现代药物与临床》2022年第6期1329-1333,共5页Drugs & Clinic

基　　金：河南省医学科技项目(LHGJ20191499)。

摘　　要：目的探讨复方氨肽素片联合卤米松乳膏治疗寻常型银屑病的临床疗效。方法选择2020年5月—2021年6月商丘市第一人民医院接诊的118例寻常型银屑病,随机分为对照组和治疗组,每组各59例。对照组于患处涂薄层卤米松乳膏,2次/d。治疗组在对照组基础上口服复方氨肽素片,5片/次,3次/d。两组患者治疗6周。观察两组患者临床疗效,比较治疗前后两组患者症状缓解时间,银屑病皮损面积严重程度指数(PASI)评分,血清因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、血管生长因子(VEGF)和白细胞介素-38(IL-38)水平,及不良反应。结果治疗后,治疗组临床有效率为98.31%,明显高于对照组的83.05%(P<0.05)。治疗后,治疗组患者出现的红斑丘疹、皮损、鳞屑、瘙痒的症状缓解时间均早于对照组(P<0.05)。治疗后,两组PASI评分均较治疗前显著降低(P<0.05),治疗组治疗后1、3、6周的PASI评分均明显低于对照组(P<0.05)。治疗后,两组患者IL-6、IL-38、TNF-α、CRP、VEGF水平均明显降低(P<0.05),且治疗组显著低于对照组。治疗组不良反应发生率为6.78%,明显低于对照组的16.95%(P<0.05)。结论复方氨肽素片联合卤米松乳膏能有效改善症状,提高疗效,缩小皮损面积,降低机体炎症反应。Objective To investigate the clinical efficacy of Compound Amino-polypeptide Tablets combined with Halometasone Cream in treatment of psoriasis vulgaris.Methods Patients(118 cases)with psoriasis vulgaris in Shangqiu First People’s Hospital from May 2020 to June 2021 were randomly divided into control and treatment group,and each group had 59 cases.Patients in the control group applied a thin layer of Halometasone Cream to the affected area,twice daily.Patients in the treatment group were po administered with Compound Amino-polypeptide Tablets on the basis of the control group,5 tablets/time,three times daily.Patients in two groups were treated for 6 weeks.After treatment,the clinical evaluation was evaluated,the relief time symptom,PASI scores,the levels of serum IL-6,IL-38,TNF-α,CRP and VEGF,and adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.31%,which was significantly higher than that of the control group(83.05%)(P<0.05).After treatment,the relief time of erythema papule,skin lesions,scales and itching in the treatment group was earlier than that in the control group(P<0.05).After treatment,PASI score in both groups was significantly lower than that before treatment(P<0.05),and PASI score in treatment group was significantly lower than that in control group at 1,3 and 6 weeks after treatment(P<0.05).After treatment,the levels of IL-6,IL-38,TNF-α,CRP and VEGF in two groups were significantly decreased(P<0.05),and the indexes in the treatment group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the treatment group was 6.78%,which was significantly lower than 16.95%in the control group(P<0.05).Conclusion Compound Amino-polypeptide Tablets combined with Halometasone Cream in treatment of psoriasis vulgaris can effectively improve the symptoms and the curative effect,reduce the area of skin lesions and the inflammatory reaction of the body.

关 键 词：复方氨肽素片 卤米松乳膏 寻常型银屑病 肿瘤坏死因子α 血管生长因子 不良反应 

分 类 号：R986[医药卫生—药品]