三唑类抗真菌药物致急性胰腺炎不良反应文献分析  

Literature analysis of adverse reactions caused by triazole antifungal drugs in acute pancreatitis

作　　者：白婷 杨蕊 朱琳 梁乐 何青青 田娜妮 李霄 惠娇娇 BAI Ting;YANG Rui;ZHU Lin;LIANG Le;HE Qing-qing;TIAN Na-ni;LI Xiao;HUI Jiao-jiao(Department of Pharmacy,the First People's Hospital of Xianyang,Xianyang 712000,China)

机构地区：[1]咸阳市第一人民医院药学部,陕西咸阳712000

出　　处：《现代药物与临床》2022年第6期1389-1393,共5页Drugs & Clinic

摘　　要：目的探讨三唑类抗真菌药物致急性胰腺炎不良反应的临床特点、发生机制及防治措施,为临床合理用药提供参考。方法检索三唑类抗真菌药物自上市以来国内外发表的关于其引起急性胰腺炎不良反应的文献,按照患者性别、年龄、饮酒史、用药情况、不良反应发生的时间、临床表现及处理方法等进行统计分析。结果共纳入8篇文献,涉及11例患者,18岁以下儿童所占比例最高(36.36%)。不良反应发生时间最短的为用药12 h,最长的为用药10周后,停药或减量或更换药品后不良反应症状可痊愈或好转。结论三唑类抗真菌药物致急性胰腺炎不良反应需引起医务人员重视,尤其是应用于儿童时。建议临床在应用三唑类抗真菌药物时,严格按照说明书的推荐剂量和疗程给药,并密切监测患者是否出现急性胰腺炎的症状。Objective To investigate the clinical characteristics,mechanism,prevention and treatment of adverse reactions of acute pancreatitis caused by triazole antifungal drugs,so as to provide reference for clinical rational drug use.Methods To search the literatures about the adverse reactions of acute pancreatitis caused by triazole antifungal drugs that have been published at home and abroad since they were listed on the market.Statistical analysis was carried out according to the patient’s gender,age,drinking history,medication,time of adverse reactions,clinical manifestations and treatment methods.Results A total of 8 literatures were included,involving 11 patients.The proportion of children under 18 years old was the highest(36.36%).The shortest time for adverse reactions to occur is 12 h after medication,and the longest is 10 weeks after medication.The symptoms of adverse reactions can be cured or improved after stopping or reducing the dose or changing the drug.Conclusion The adverse reactions of acute pancreatitis caused by triazole antifungal drugs should be paid attention to by medical staff,especially when used in children.It is suggested that the clinical application of triazole antifungal drugs should be strictly in accordance with the recommended dose and course of treatment in the manual,and patients should be closely monitored for symptoms of acute pancreatitis.

关 键 词：三唑类抗真菌药物 急性胰腺炎 不良反应 酮康唑 伏立康唑 氟康唑 伊曲康唑 艾沙康唑 泊沙康唑 

分 类 号：R978.5[医药卫生—药品]