麦门冬汤化学成分及治疗肺纤维化研究进展  

Research Progress on the Chemical Components of Maimendong Decoction(麦门冬汤) and Its Treatment Pulmonary Fibrosis

作　　者：任娟宁 范文京 李彤[1] 雷鹏 战秀俊 董鹏志[1] 姜苗苗[1] REN Juanning;FAN Wenjing;LI Tong;LEI Peng;ZHAN Xiujun;DONG Pengzhi;JIANG Miaomiao(State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]组分中药国家重点实验室,天津中医药大学,天津301617

出　　处：《辽宁中医药大学学报》2022年第6期155-159,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81573547);天津市科技计划项目(20ZYJDJC00120);天津市自然科学基金项目(18JCZDJC97700)。

摘　　要：肺纤维化是肺功能障碍和呼吸衰竭的主要病理基础。其发病率逐年上升,被列为影响人类健康的重大疾病之一。中医药在肺部疾病防治方面具有不良反应小、改善患者整体病理状态、提高生活质量等优势。麦门冬汤由麦门冬、半夏、人参、甘草、粳米、大枣六味药组成,主要用于治疗肺纤维化,临床研究证明其具有抗炎、抗氧化、抗纤维化等作用。该研究主要从其化学成分、肺纤维化治疗、药理作用及作用机制等几个方面进行论述,以期为临床治疗肺纤维化研究提供理论依据,为后续中医药治疗肺纤维化提供参考及启发。Pulmonary fibrosis is the main pathological basis of lung dysfunction and respiratory failure.The incidence rate is increasing year by year,and it is listed as one of the major diseases affecting human health.Traditional Chinese medicine has the advantages of less toxic and side effects in the prevention and treatment of lung diseases,improving the overall pathological state of patients,and improving the quality of life.Maimendong Decoction(麦门冬汤)is composed of six medicines of Maidong(Ophiopogonis Radix),Banxia(Pinelliae Rhizoma),Renshen(Ginseng Radix Et Rhizoma),Gancao(Glycyrrhizae Radix Et Rhizoma),Jingmi(Oryza sativa),Dazao(Jujubae Fructus).It is mainly used to treat pulmonary fibrosis.Preclinical studies have proved that it has anti-inflammatory,anti-oxidant and anti-fibrotic effects.This study mainly discusses its chemical composition,pulmonary fibrosis treatment,pharmacological effects and mechanism of action,etc.,in order to provide a theoretical basis for clinical treatment of pulmonary fibrosis,and provide reference and inspiration for follow-up Chinese medicine treatment of pulmonary fibrosis.

关 键 词：麦门冬汤 化学成分 肺纤维化治疗 药理作用 作用机制 

分 类 号：R563[医药卫生—呼吸系统]