羊口疮病毒维持O⁃H感染系统的稳态机制  

Homeostatic Mechanism of the Orf Virus–Host Infection System Maintained by the Orf Virus

作　　者：于永忠[1] 张帆 杨超群 刘圆圆 杨晓 崔玉东[1] YU Yongzhong;ZHANG Fan;YANG Chaoqun;LIU Yuanyuan;YANG Xiao;CUI Yudong(The Molecular Viral Laboratory,College of Biological Science and Technology,Heilongjiang Bayi Agricultural University,Daqing 163319,China)

机构地区：[1]黑龙江八一农垦大学生命科学技术学院分子病毒实验室,大庆163319

出　　处：《病毒学报》2022年第4期1007-1015,共9页Chinese Journal of Virology

基　　金：国家自然科学基金面上项目(项目号:31172353),题目:羊传染性脓疱病毒保护性抗原表位筛选及表位作图研究;黑龙江省自然科学基金面上项目(项目号:C2017052),题目:羊口疮病毒B2L蛋白类磷脂酶⁃D活性分析和分子特征研究;黑龙江八一农垦大学研究生创新科研项目(项目号:YJSCX2019⁃Y67),题目:荷兰马齿苋不饱和脂肪酸抗ORFV感染的分子机制。

摘　　要：羊口疮病毒(Orf virus,ORFV)是副痘病毒属(Parapoxvirus,PPV)典型的代表成员,具有鲜明的种属特征。ORFV具有高度的上皮嗜性,并不侵入真皮层,通常导致皮肤或黏膜上皮严重的病理性损伤;并且容易造成继发性感染。近年来,随着ORFV与宿主细胞“互作”机制研究的不断深入,病毒进化的细胞策略初露端倪。为了揭示其较为完整的细胞策略,我们借助“ORFV⁃HOST”(O⁃H)系统全方位阐述病毒与宿主建立的互作关系。本综述旨在挖掘病毒感染期间维持O⁃H系统稳态的目的、意义及其分子机制,为丰富ORFV分子病毒学理论和羊口疮抗病毒设计提供了参考。The Orf virus(ORFV)is a representative member of the genus Parapoxvirus,but there are distinct differences between species.The ORFV tends to favor the epithelium and does not invade the dermis.Usually,this phenomenon results in severe pathological damage to the skin or mucosal epithelium,which can lead to secondary infections.In recent years,with greater understanding of the interactions between the ORFV and host cells,a cellular strategy of viral evolution has started to emerge.To reveal this cellular strategy more completely,we illustrated the relationship between the virus and host with the“ORFV–HOST”(O–H)system.This review explores the purpose,importance,and molecular mechanism by which homeostasis of the O⁃H system is maintained during viral infection.Our review provides a reference to enrich the theory of ORFV molecular virology and antiviral design against orf.

关 键 词：羊口疮病毒 基因组演化 O⁃H系统 感染稳态 分子机制 

分 类 号：S852.654[农业科学—基础兽医学]