肺表面活性蛋白-D功能及其在肺部常见疾病中的研究进展  

Research progress on the function of surfactant protein-D and its role in the common lung diseases

作　　者：刘娟丽[1,2] 马四清 陈强[1] Liu Juanli;Ma Siqing;Chen Qiang(Department of Critical Care Medicine,Qinghai Provincial People′s Hospital,Xining 810007,China;Plateau Medical Center of Qinghai University,Xining 810001,China)

机构地区：[1]青海省人民医院重症医学科,西宁810007 [2]青海大学高原医学研究中心,西宁810001

出　　处：《中华重症医学电子杂志》2022年第2期167-172,共6页Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)

基　　金：国家自然科学基金项目(81860351);青海省高原重症医学重点实验室项目(2020-81);青海省高原医学应用基础重点实验室(青海-犹他高原医学联合重点实验室)项目(2022-ZJ-Y15)。

摘　　要：肺表面活性蛋白-D(SP-D)是凝集素家族糖蛋白,主要在肺部的肺泡Ⅱ型上皮细胞和无纤毛细支气管上皮细胞合成和分泌,储存在Clara细胞的分泌颗粒中。SP-D是表面结合蛋白之一,也是组成肺表面活性系统的一部分。SP-D除了有助于肺泡空间内表面活性剂池稳态外,还具有宿主防御和免疫调节功能。本文通过对近年来SP-D在肺部常见疾病中的部分相关研究进行总结,为众多肺部疾病,特别是肺部炎症性疾病潜在的治疗提供重要的方法理论基础。Lung surfactant protein D(SP-D)is a glycoprotein of the lectin family.In lungs it is synthesized and secreted mainly in the alveolar typeⅡepithelial cells and non-ciliated bronchiole epithelial cells,and are stored in secretory granules of Clara cells.SP-D is one of the surfactant binding proteins and is also a part of the pulmonary surfactant system.In addition to contributing to the homeostasis of surfactant pools in alveolar space,SP-D also exhibits functions of host defense and immunoregulation.This paper summarizes some relevant studies on SP-D in acute lung diseases in recent years,providing important theoretical basis for the potential treatment of many lung diseases,especially in inflammatory lung diseases.

关 键 词：表面活性蛋白-D 表面活性剂池稳态 宿主防御 免疫调节 

分 类 号：R56[医药卫生—呼吸系统]