磷脂过氧化在冠心病发病机制中的研究进展  

Research advances of phospholipid peroxidation in pathogenesis of coronary heart disease

作　　者：马晓慧 刘江涵子 罗淦清 李怡芳[1,2,3] 栗原博[1,2,3] 何蓉蓉[1,2,3] MA Xiao-hui;LIU Jiang-han-zi;LUO Gan-qing;LI Yi-fang;LI Yuan-bo;HE Rong-rong(Guangdong Province Research and Development Center for Chinese Medicine in Disease Susceptibility,Jinan University,Guangzhou 510632,China;College of Pharmacy,Jinan University,Guangzhou 510632,China;Guangdong Key Laboratory of Research of Medicinal Substance Basis of Traditional Chinese Medicine and Innovative Drugs,Jinan University,Guangzhou 510632,China;Institute of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830054,China;Institute of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China)

机构地区：[1]暨南大学广东省疾病易感性及中医药研发工程技术研究中心,广东广州510632 [2]暨南大学药学院,广东广州510632 [3]暨南大学广东省中药药效物质基础及创新药物研究重点实验室,广东广州510632 [4]新疆医科大学中医学院,新疆乌鲁木齐830054 [5]暨南大学中医学院,广东广州510632

出　　处：《中国药理学通报》2022年第8期1121-1127,共7页Chinese Pharmacological Bulletin

基　　金：国家重点研发项目(No.2017YFC1700404);国家自然科学基金青年项目(No.81904068)。

摘　　要：冠心病是一种冠状动脉粥样硬化性心脏病,严重危害人类健康,已成为全球亟待解决的健康问题之一。目前,流行病学研究认为,脂质代谢异常是一种危险因素在冠心病过程中具有重要作用,对该危险因素进行积极预防可显著降低冠心病的发病率及死亡率。大量研究发现,脂质过氧化贯穿于整个冠心病的疾病过程中。为了深入了解脂质过氧化对冠心病发病机制的影响,该文从ALOX15介导的磷脂过氧化角度总结了冠心病的发病进程的作用机制,关注ALOX15抑制剂的作用,为更好地预防、治疗冠心病及其并发症提供新的思路与策略。Coronary heart disease(CHD)is a kind of coronary atherosclerotic cardiovascular disease that seriously endangers human health and needs to be solved urgently in the world.Epidemiologically,abnormal lipid metabolism has been found to be a significant risk factor and preventing it could obviously improve the incidence rate and mortality.A large number of studies suggest that lipid peroxidation exists through the whole process of CHD.To deeply understand the mechanism of lipid peroxidation in the pathogenesis of CHD,this review focuses on the angle of ALOX15-mediated phospholipid peroxidation and the effect of ALOX15 inhibitors,expecting to provide new molecular markers and potential therapeutic targets for the precaution and treatment of CHD.

关 键 词：冠心病 动脉粥样硬化 心肌细胞损伤 铁死亡 磷脂过氧化 ALOX15 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R329.411[医药卫生—基础医学] R344.5R541.4R543.3