基于睾丸微环境探讨支持细胞及管周肌样细胞对间质细胞合成睾酮的影响  

Effects of Sertoli cells and peritubular myoid cells on testosterone synthesis in Leydig cells:Analysis based on the testicular microenvironment

作　　者：吴悔 宁港(综述) 周兴(审校)[2] WU Hui;NING Gang;ZHOU Xing(Hunan University of Chinese Medicine,Changsha,Hunan 410006,China;Department of Andrology,The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410007,China)

机构地区：[1]湖南中医药大学,湖南长沙410006 [2]湖南中医药大学第一附属医院男科,湖南长沙410007

出　　处：《中华男科学杂志》2022年第6期534-537,共4页National Journal of Andrology

基　　金：国家自然科学基金(82074444,81673984);湖南创新型省份建设专项经费资助-“湖湘青年英才”支持计划(2019RS2041);湖南省教育厅重点项目(20A368);长沙市科技计划项目经费资助-长沙市杰出创新青年培养计划(kq1802015);湖南省高层次卫生人才225工程医学学科骨干人才培养对象(湘卫函[2019]196号)。

摘　　要：近年来,对于睾丸微环境的深入研究取得了一定的进展,为相关疾病的诊治与预防提供了新的思路。睾酮是男性体内重要的雄激素,其水平调控着男性的生理功能。睾酮的合成是一个极其复杂的过程,主要在睾丸间质细胞中进行。但随着大量研究的深入,更多地证据表明构成睾丸微环境的睾丸支持细胞和睾丸管周肌样细胞在睾酮合成过程中也发挥着举足轻重的作用。本综述将从睾丸微环境的角度分析间质细胞合成睾酮的过程及支持细胞和管周细胞对其产生的影响,以期为治疗和预防男性疾病提供参考依据。Recent progress in the studies of testicular microenvironment has provided some new ideas on the diagnosis,treatment and prevention of related diseases.Testosterone,as an important androgen in men,regulates the physiological functions of males.The synthesis of testosterone is an extremely complex process,which mainly takes place in Leydig cells.However,Sertoli cells and testicu-lar peritubular myoid cells,which constitute the testicular microenvironment,also play an essential role in the process of testosterone synthesis.This review focuses on the process of Leydig cells synthesizing testosterone and the effects of Sertoli cells and testicular per-itubular myoid cells on testosterone synthesis from the perspective of testicular microenvironment,aiming to provide reference for the treatment and prevention of male diseases.

关 键 词：睾酮 睾丸微环境 睾丸间质细胞 睾丸支持细胞 管周肌样细胞 

分 类 号：R339.21[医药卫生—人体生理学]