胶原蛋白在血管移植物中的应用研究进展  

On Advance in the Application of Collagen to Vascular Grafts

作　　者：王涵[1,2] 杨敏一[1] 王蕊 李楠 韩倩倩 王春仁[1] Wang Han;Yang Minyi;Wang Rui;Li Nan;Han Qianqian;Wang Chunren(National Institutes for Food and Drug Control,Beijing 102629,China;Beijing Institute of Technology,Beijing 100081,China)

机构地区：[1]中国食品药品检定研究院,北京102629 [2]北京理工大学,北京100081

出　　处：《中国药事》2022年第7期836-842,共7页Chinese Pharmaceutical Affairs

基　　金：中国科学院“器官重建与制造”战略性先导专项(编号XDA16040602)。

摘　　要：目的:全面探讨胶原蛋白在血管移植物中的作用,为血管移植物的研究及开发提供参考。方法:通过PubMed数据库查阅国内外关于应用胶原蛋白进行血管移植物制备的相关研究文献,并对其进行整理、汇总。结果与结论:胶原蛋白是体内主要蛋白质之一,在血管壁的三层均有分布。它有利于血管内皮细胞生长及平滑肌细胞的附着,能维持血管壁的机械性能,与血管疾病的发生密切相关。胶原蛋白是具有良好的生物相容性、生物活性及可降解性的生物材料,可作为血管涂层、血管支架原材料或者与细胞联合应用以构建血管移植物并显示了良好的效果。在制备工艺方面,铸造和纺丝是目前大规模生产胶原蛋白血管移植物的主要方法,而3D打印等新的技术也在不断发展,并在血管移植物的制造中得到应用。随着制造、材料、医学技术的不断发展,胶原蛋白仍是未来用于制备血管移植物的理想原材料。Objective:To comprehensively study the roles of collagen in vascular grafts and provide references for the research and development of vascular grafts.Methods:Relevant literature on the fabrication of vascular grafts with the application of collagen at home and abroad was searched through the PubMed database,and the data was sorted out and summarized.Results and Conclusion:Collagen is one of the predominant proteins in the body distributing over the three layers of the vascular wall.It will benefit the growth of vascular endothelial cells and the attachment of smooth muscle cells and will maintain the mechanical properties of vascular walls,so it is associated closely with the development of vascular diseases.Collagen is a biomaterial with good biocompatibility,bioactivity and biodegradability.It can be used as blood vessel coating and raw material of vascular scaffold or it can be combined with cells to construct vascular grafts and has shown good results.In terms of fabrication technology,casting and spinning are currently the main methods for large-scale production of collagen vascular grafts,at the same time 3 D printing and other new technologies are constantly developing and being used in the manufacture of vascular grafts.With the continuous development of manufacturing,materials and medical technology,collagen is still an ideal raw material for the fabrication of vascular grafts in the future.

关 键 词：胶原蛋白 生物材料 血管移植物 类人胶原蛋白 制备 

分 类 号：R917[医药卫生—药物分析学]