乳杆菌活菌胶囊对不同细菌感染盆腔炎后遗症患者的作用  

The efficacy of Lactobacillus capsules on pelvic inflammatory disease patients with different bacterial infections

作　　者：吴兴花 倪银芳 齐育英 刘锦玉 张丽 陈锦果 WU Xing-hua;NI Yin-fang;QI Yu-ying;LIU Jin-yu;ZHANG Li;CHEN Jin-guo(Department of Obstetrics and Gynecology,Ningde City Hospital,Ningde,Fujian 352100,China;不详)

机构地区：[1]宁德师范学院附属宁德市医院妇产科,福建352100 [2]宁德师范学院附属宁德市医院检验科

出　　处：《中国微生态学杂志》2022年第6期701-704,710,共5页Chinese Journal of Microecology

摘　　要：目的研究乳杆菌活菌胶囊对不同细菌感染盆腔炎后遗症患者的疗效及其阴道菌群失调的相关影响因素。方法本研究采用前瞻性研究,以2017年2月至2020年1月在我院进行治疗的120例盆腔炎后遗症患者作为研究对象,包括乙型溶血性链球菌感染患者44例,粪肠球菌感染患者10例,大肠埃希菌感染患者36例,金黄色葡萄球菌感染患者30例。按照随机分组原则,将以上患者随机分为观察组和对照组,每组患者60例,所有患者均采用甲硝唑进行治疗,观察组患者在此基础上联合采用乳杆菌活菌制剂进行治疗,两组患者均治疗10 d。比较两组患者的治疗效果、阴道菌群失调情况以及观察组中不同细菌感染患者的疗效差异。分析影响患者治疗效果的因素。结果观察组患者治疗总有效率(91.67%)显著高于对照组(78.33%),差异有统计学意义(χ^(2)=4.182,P=0.041)。治疗后,观察组患者阴道菌群密度(χ^(2)=4.681,P=0.031)、多样性(χ^(2)=4.912,P=0.027)以及阴道微生态情况(χ^(2)=8.081,P=0.005)均优于对照组。金黄色葡萄球菌感染患者的治疗效果显著高于其他细菌感染患者(χ^(2)=8.410,P=0.038)。治疗有效组和治疗无效组患者外阴清洗规律率、内衣裤混洗频率、内裤面料以及既往盆腔炎后遗症之间的差异有统计学意义(均P<0.05)。外阴清洗、内衣裤混洗、内裤面料、既往盆腔炎后遗症均是影响患者治疗效果的影响因素。结论乳杆菌活菌胶囊对于金黄色葡萄球菌感染盆腔炎后遗症患者的治疗效果显著。治疗中建议对个人卫生习惯不良的患者进行宣教,提升患者的治疗效果。Objective To observe the efficacy of Lactobacillus capsules on pelvic inflammatory disease(PID)patients with different bacterial infections and related influencing factors of vaginal flora imbalance.Methods In this prospective study,120 patients with PID treated in our hospital from February 2017 to January 2020 were selected as the subjects,including 44 patients with hemolytic Streptococcus B infection,10 with Enterococcus faecalis infection,36 with Escherichia coli infection and 30 with Staphylococcus aureus infection.The above patients were randomly divided into observation group or control group,60 cases in each group.All the patients were treated with Metronidazole(Metronidazole).The observation group was additionally treated with Lactobacillus preparation.Both groups were treated for 10 days.The treatment effect,vaginal flora imbalance and effectiveness were compared between groups and among patients with different bacterial infections in the observation group.The influencing factors of treatment effect were analyzed.Results The total efficiency rate in the observation group(91.67%)was significantly higher than that in the control group(78.33%)(χ^(2)=4.182,P=0.041).After treatment,the vaginal bacterial density(χ^(2)=4.681,P=0.031),diversity(χ^(2)=4.912,P=0.027)and vaginal microecology(χ^(2)=8.081,P=0.005)in the observation group were better than those in the control group.The treatment effect in patients with Staphylococcus aureus infection was significantly higher than that in those with other bacterial infections(χ^(2)=8.410,P=0.038).There were statistically significant differences in the rate of regular vulva cleaning,frequency of mixed washing of underwears,underwear fabric and previous pelvic inflammatory diseases between patients achieving effective treatment and those with treatment failure(all P<0.05).Mixed washing,underwear fabric and previous PID were the influencing factors of treatment effect.Conclusion Lactobacillus capsule is effective for the treatment of pelvic inflammatory disease pati

关 键 词：乳杆菌活菌胶囊 盆腔炎后遗症 菌群失调 细菌感染 

分 类 号：R711.33[医药卫生—妇产科学]