基于“肠道菌群-脂质-线粒体”稳态失衡探讨“从脾论治”动脉粥样硬化  

Treating Atherosclerosis from Spleen Based on Homeostasis Imbalance of“Intestinal Flora-Lipid-Mitochondria”

作　　者：崔运浩[1] 裘雪莹 贾连群[1] 宋囡[1] CUI Yunhao;QIU Xueying;JIA Lianqun;SONG Nan(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847

出　　处：《中华中医药学刊》2022年第6期134-136,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81774022);辽宁省“兴辽英才计划”(XLYC1902100)。

摘　　要：动脉粥样硬化与机体内环境稳态失衡密切相关。肠道菌群失调、血脂异常、线粒体代谢障碍等稳态失衡,导致动脉粥样硬化发生发展。中医理论认为,脾虚失于健运,聚湿生痰,日久生瘀,痰瘀互结阻于脉道,导致动脉粥样硬化。从“肠道菌群-脂质-线粒体”稳态失衡,探讨“从脾论治”动脉粥样硬化。Atherosclerosis is closely related to the imbalance of homeostasis.The imbalance of intestinal flora,dyslipidemia and mitochondrial metabolism lead to the occurrence and development of atherosclerosis.According to the theory of traditional Chinese medicine,spleen deficiency leads to the failure of transportation,the accumulation of dampness and phlegm,the generation of blood stasis and the mutual accumulation of phlegm and blood stasis obstructing the vessels,leading to atherosclerosis.This paper discussed the treatment of atherosclerosis from spleen from the homeostasis imbalance of“intestinal flora-lipid-mitochondria”.

关 键 词：动脉粥样硬化 稳态 从脾论治 肠道菌群 血脂 线粒体 

分 类 号：R259.431[医药卫生—中西医结合]