HIF-1在RA发病机制中的作用  

Research Progress on Hypoxia-Inducible Factor-1 in Pathogenesis of Rheumatoid Arthritis

作　　者：蒋雨晴 赵小艳 张鑫 卢群文 苏程果 朱俊[1] JIANG Yu-qing;ZHAO Xiao-yan;ZHANG Xin;LU Qun-wen;SU Cheng-guo;ZHU Jun(College of Acupuncture and Tuina/The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610072;Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610075)

机构地区：[1]成都中医药大学针灸推拿学院/第三附属医院,四川成都610072 [2]成都中医药大学附属医院,四川成都610075

出　　处：《按摩与康复医学》2022年第17期45-49,共5页Chinese Manipulation and Rehabilitation Medicine

基　　金：国家自然科学基金项目,编号:81704152;四川省科技厅项目,编号:2019YJ0491。

摘　　要：类风湿关节炎(RA)是临床常见的免疫性疾病之一,关节滑膜的炎性浸润、滑膜细胞“肿瘤样”过渡增殖及软骨的破坏是RA的主要病理特征。低氧诱导因子-1(HIF-1)是一种由低氧诱导细胞产生的调节氧稳态的核转录因子,研究表明其参与了RA的发病和病情进展。本文就目前HIF-1的结构、表达、调节及其在RA发病中相关作用进行综述。Rheumatoid arthritis(RA)is one of the common immune diseases in clinic.Inflammatory infiltration of joint synovium,"tumor-like"transitional proliferation of synovial cells and destruction of cartilage are the main pathological features of RA.Hypoxia inducible factor-1(HIF-1)is a nuclear transcription factor produced by hypoxia-induced cells to regulate oxygen homeostasis.Studies have shown that HIF-1 is involved in the onset and progression of RA.This article reviews the structure,expression,regulation of HIF-1 and its related role in RA.

关 键 词：类风湿关节炎 低氧诱导因子-1(HIF-1) 低氧 滑膜 发病机制 

分 类 号：R593.22[医药卫生—内科学]