星状神经节阻滞术治疗带状疱疹后神经痛临床效果及安全性的meta分析  

Meta-analysis of clinical efficacy and safety of stellate ganglion block in the treatment of postherpetic neuralgia

作　　者：穆强 柴俊龙[1] 吕宏林 任达 刘文华 黄媛馨 王林 MU Qiang;CHAI Junlong;LYU Honglin;REN Da;LIU Wenhua;HUANG Yuanxin;WANG Lin(Department of Pain,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Province,Cangzhou061012,China;Department of Pain,Affiliated Hospital of Guizhou Medical University,Guizhou Province,Guiyang550001,China)

机构地区：[1]河北省沧州中西医结合医院疼痛科,河北沧州061012 [2]贵州医科大学附属医院疼痛科,贵州贵阳550001

出　　处：《中国医药导报》2022年第19期103-106,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(82060811);贵州省科技计划项目(黔科合基础-ZK[2021]一般508)。

摘　　要：目的评价星状神经节阻滞术治疗带状疱疹后神经痛的效果及安全性。方法计算机检索Pub Med、The Cochrane Library、Embase、CNKI、CBM、VIP、Wangfang Data中关于星状神经节阻滞术治疗带状疱疹后神经痛的随机对照试验,检索期限为建库至2021年4月。根据Cochrane偏倚风险评估工具对筛选所得文献进行评估,之后采用Rev Man 5.4版本软件进行meta分析。结果共筛选8篇文献。meta分析结果显示,试验组总有效率高于对照组(OR=4.50,95%CI:2.18~9.27,P<0.0001),试验组治疗后疼痛评分低于对照组(MD=-0.66,95%CI:-0.87~-0.45,P<0.00001)。两组不良反应发生率比较,差异无统计学意义(OR=0.58,95%CI:0.27~1.22,P=0.15)。结论星状神经节阻滞术治疗带状疱疹后神经痛可明显提高总有效率、减轻患者疼痛症状,是一种安全有效的方法。Objective To evaluate the efficacy and safety of stellate ganglion block in the treatment of postherpetic neuralgia.Methods The randomized controlled trials of stellate ganglion block in the treatment of postherpetic neuralgia were searched in Pub Med,The Cochrane Library,Embase,CNKI,CBM,VIP,and Wangfang Data from inception to April 2021.The selected literatures were evaluated according to the Cochrane bias risk assessment tool,and then the Rev Man 5.4 version of the software was used for meta-analysis.Results A total of eight literatures were screened.Meta-analysis showed that the total effective rate of treatment in experimental group was higher than that in control group(OR=4.50,95%CI:2.18 to 9.27,P<0.0001),and the pain score after treatment in experimental group was lower than that in control group(MD=-0.66,95%CI:-0.87 to-0.45,P<0.00001).There was no significant difference in the incidence of adverse reactions between the two groups(OR=0.58,95%CI:0.27 to 1.22,P=0.15).Conclusion Stellate ganglion block is a safe and effective treatment for postherpetic neuralgia,which can obviously improve the total effective rate and relieve pain symptoms.

关 键 词：星状神经节阻滞术 带状疱疹后神经痛 临床疗效 随机对照试验 META分析 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]