槐杞黄颗粒联合中医肠动力干预治疗儿童便秘的研究  

Study on the treatment of constipation in children by combining Huaiqihuang granules with traditional Chinese medicine intestinal motility intervention

作　　者：王玉娇 韩艳珺[1] 贺媛媛[1] 韩红 路娟 WANG Yujiao;HAN Yanjun;HE Yuanyuan;HAN Hong;LU Juan(First Department of Pediatrics,Xingtai People′s Hospital,Xingtai,Hebei 054000,China)

机构地区：[1]河北省邢台市人民医院儿一科,河北邢台054000

出　　处：《国际检验医学杂志》2022年第15期1831-1834,1838,共5页International Journal of Laboratory Medicine

基　　金：河北省中医药管理局科研计划项目(2019512)。

摘　　要：目的探讨槐杞黄颗粒联合中医肠动力干预治疗儿童便秘的疗效,以及其对儿童肠道微生态和血清肽类激素酪酪肽(PYY)、血管活性肠肽(VIP)水平的影响。方法前瞻性选取2019年8月至2020年8月在该院就诊的120例便秘患儿作为研究对象,采用随机数字表法将患儿分为对照组和观察组,每组60例。对照组给予基础治疗联合乳果糖治疗,观察组在对照组治疗基础上采用槐杞黄颗粒联合中医肠动力干预进行治疗。所有患儿均治疗4周。比较两组临床疗效及不良反应发生情况,比较治疗前后便秘状况评分、肠道主要菌群水平和血清PYY、VIP水平。结果观察组临床有效率为91.7%,明显高于对照组的76.7%(P<0.05)。治疗前两组便秘状况各项评分、肠道主要菌群水平及血清PYY、VIP水平差异均无统计学意义(P>0.05)。治疗后两组便秘状况各项评分、肠道大肠杆菌和葡萄球菌水平及血清VIP水平较治疗前均明显降低(P<0.05),且观察组便秘状况各项评分、肠道大肠杆菌和葡萄球菌水平及血清VIP水平均明显低于对照组(P<0.05);治疗后两组肠道益生菌群乳酸杆菌、双歧杆菌水平及血清PYY水平较治疗前均明显升高(P<0.05),且观察组肠道益生菌群乳酸杆菌、双歧杆菌水平及血清PYY水平均明显高于对照组(P<0.05)。观察组不良反应发生率为18.3%,对照组为21.7%,差异无统计学意义(P>0.05)。结论槐杞黄颗粒联合中医肠动力干预治疗患儿便秘,能提高临床疗效,改善患儿肠道菌群水平,提高血清PYY水平,降低血清VIP水平,有效缓解便秘,并且可保证安全性。Objective To investigate the efficacy of Huaiqihuang granules combined with traditional Chinese medicine intestinal motility intervention in the treatment of constipation in children,and their effects on children′s intestinal microecology,serum peptide hormones peptide YY(PYY)and vasoactive intestinal peptide(VIP)levels.Methods A total of 120 children with constipation who were treated in this hospital from August 2019 to August 2020 were prospectively selected as the research objects,and they were divided into the control group and the observation group by random number table method,with 60 cases in each group.The control group was given basic treatment combined with lactulose treatment,and the observation group was given Huaiqihuang granules combined with traditional Chinese medicine intestinal motility intervention on the basis of the treatment of the control group.All the children were treated for 4 weeks.The clinical efficacy and the occurrence of adverse reactions were compared between the two groups,and the scores of constipation status,the level of main intestinal flora and the levels of serum PYY and VIP were compared before and after treatment.Results The clinical effective rate of the observation group was 91.7%,which was significantly higher than that of the control group(P<0.05).Before treatment,there were no statistically significant differences in the scores of constipation status,the level of major intestinal flora and the levels of serum PYY and VIP between the two groups(P>0.05).After treatment,the scores of constipation status,the levels of intestinal Escherichia coli and Staphylococcus and the level of serum VIP were significantly lower than those before treatment(P<0.05),and the scores of constipation status,the levels of intestinal Escherichia coli and Staphylococcus and the level of serum VIP in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of intestinal probiotics Lactobacillus,Bifidobacterium and serum PYY in the two gr

关 键 词：便秘 槐杞黄颗粒 中医肠动力干预 肠道微生态 酪酪肽 血管活性肠肽 

分 类 号：R725.7[医药卫生—儿科] R459.9[医药卫生—临床医学]