易栓症不良妊娠患者的发病机制和血液学变化  

Pathogenesis and hematological changes in patients with thrombophilia in adverse pregnancy

作　　者：张秀玲 杨春(综述)[1] 姜晓峰(审校)[1] ZHANG Xiuling;YANG Chun;JIANG Xiaofeng(Department of Clinical Laboratory,the Fourth Hospital of Harbin Medical University,Harbin Heilongjiang 150028,China)

机构地区：[1]哈尔滨医科大学附属第四医院检验科,黑龙江哈尔滨150028

出　　处：《国际检验医学杂志》2022年第15期1894-1899,共6页International Journal of Laboratory Medicine

摘　　要：在妊娠过程中,母体的凝血、抗凝及纤溶系统会发生改变,使母体处于高凝状态,而高凝状态过强将导致易栓症的发生。易栓症引起患者胎盘循环不足,营养减少,继而发生不良妊娠结局。因患者处于高凝状态,故凝血系统可增强,进而导致抗凝和纤溶系统功能也进一步增强,但当抗凝或纤溶系统功能减弱时也可间接导致易栓症的形成。该文总结了国内外文献中关于遗传性易栓症及获得性易栓症引起的不良妊娠结局的机制和检测指标,希望能为临床易栓症的诊断及不良妊娠结局的治疗提供更全面帮助,以便早期对易栓症进行干预,减少不良妊娠结局的发生。During pregnancy,the mother′s coagulation,anticoagulation and fibrinolysis systems will change,leaving the mother in a hypercoagulable state,and over strong of this state will lead to the occurrence of thrombophilia.Thrombophilias cause insufficient placental circulation,reduced nutrition,and adverse pregnancy outcomes.Because the patient is in a hypercoagulable state,the coagulation system can be enhanced,which will further enhance the function of the anticoagulation and fibrinolysis systems.However,when the function of the anticoagulation or fibrinolysis system is weakened,it can also indirectly lead to the formation of thromboembolia.This article summarizes the domestic and foreign literature on the mechanism and detection indicators of adverse pregnancy outcomes caused by hereditary thrombophilia and acquired thrombophilia,hoping to provide more comprehensive help for the diagnosis of clinical thrombophilia and the treatment of adverse pregnancy outcomes,so it can intervene thrombophilia in early time,and reduce the occurrence of adverse pregnancy outcomes.

关 键 词：易栓症 不良妊娠结局 血液学指标 

分 类 号：R714.25[医药卫生—妇产科学]