沙棘干乳剂联合布拉氏酵母菌治疗儿童轮状病毒性肠炎的效果及对免疫功能的影响  

Effect of seabuckthorn dry emulsion combined with Saccharomyces boulardii in treatment of rotavirus enteritis in children and its influence on immune function

作　　者：张伟伟 李园园 ZHANG Wei-wei;LI Yuan-yuan(Shaoling District People's Hospital of Luohe City,Luohe 462300,Henan,China)

机构地区：[1]漯河市召陵区人民医院,河南漯河462300

出　　处：《中国校医》2022年第6期452-455,共4页Chinese Journal of School Doctor

摘　　要：目的 探讨沙棘干乳剂联合布拉氏酵母菌治疗儿童轮状病毒性肠炎的临床效果。方法 以随机数字表法,将2019年10月—2021年2月收治的106例轮状病毒性肠炎患儿予以分组,对照组53例,给予布拉氏酵母菌治疗,观察组53例,在对照组基础上,加用沙棘干乳剂治疗,对2组临床疗效,症状消失时间,治疗前、后免疫功能变化及用药安全性予以观察。结果 治疗总有效率观察组为96.23%,与照组治疗总有效率84.91%比较,明显较高,差异有统计学意义(χ^(2)=3.975,P<0.05);观察组患儿发热、腹泻、呕吐消失时间为(2.14±0.36)d、(2.75±0.48)d、(1.86±0.31)d,与对照组(2.59±0.42)d、(3.19±0.51)d、(2.24±0.39)d比较,明显较短,差异有统计学意义(t =5.922、4.574、5.553,P 均<0.05);治疗 3 d 后,观察组血清免疫球蛋白 A(IgA)、免疫球蛋白 M(IgM)、免疫球蛋白 G(IgG)水平为(1.58±0.39)g/L、(1.45±0.33)g/L、(9.82±1.06)g/L,与同期对照组(1.31±0.32)g/L、(1.24±0.31)g/L、(8.96±1.02)g/L比较,明显较高,差异有统计学意义(t =3.896、3.393、4.256,P 均<0.05);不良反应发生率观察组、对照组分别为3.77%、7.55%,差异无统计学意义(χ^(2)=0.177,P>0.05)。结论 沙棘干乳剂联合布拉氏酵母菌治疗儿童轮状病毒性肠炎,可促进患儿症状恢复,提高患儿免疫功能,疗效确切,安全性高,值得推广。ObjectiveTo explore the clinical effect of seabuckthorn dry emulsion combined with Saccharomyces boulardii in the treatment of rotavirus enteritis in children.MethodsA random number table method was used to divide106 children with rotavirus enteritis admitted from Oct 2019 to Feb 2021 into 2 groups, and 53 cases in the control group were treated with Saccharomyces boulardii, and 53 cases in the observation group were treated with seabuckthorn dry emulsion on the basis of the control group. The clinical efficacy, the time of symptom disappearance, the changes of immune function before and after the treatment and the medication safety of the two groups were observed and compared.ResultsIn the observation group, the total effective rate was 96.23%, higher than 84.91% in the control group, and the difference was statistically significant (χ^(2)= 3.975, P < 0.05). The disappearance time of fever, diarrhea and vomiting in the observation group were (2.14 ± 0.36) d, (2.75 ± 0.48) d, (1.86 ± 0.31) d, shorter than (2.59 ± 0.42) d, (3.19 ± 0.51) d, (2.24 ± 0.39) d in the control group, and the differences were statistically significant (t = 5.922, 4.574, 5.553, all P < 0.05). After 3 days of the treatment, the levels of the serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) in the observation group were (1.58 ± 0.39) g/L, (1.45 ± 0.33) g/L, and (9.82 ± 1.06) g/L respectively, higher than (1.31 ± 0.32) g/L,(1.24 ± 0.31) g/L, and (8.96 ± 1.02) g/L in the control group at the same period, and the differences were statistically significant (t = 3.896, 3.393, 4.256, all P < 0.05). The incidence of adverse reactions in the observation group and control group were 3.77% and 7.55% respectively, and the difference was not statistically significant (χ^(2)=0.177, P > 0.05).Conclusions Seabuckthorn dry emulsion combined with Saccharomyces boulardii in the treatment of rotavirus enteritis in children can promote the recovery of symptoms and improve the immune function of the children. It has a

关 键 词：轮状病毒性肠炎 沙棘干乳剂 布拉氏酵母菌 免疫功能 

分 类 号：R516.1[医药卫生—内科学]