2型糖尿病合并胆囊结石的发病机制  

Pathogenesis of Type 2 Diabetes Mellitus Combined with Cholecystolithiasis

作　　者：罗锦涛 潘耀振 杨婧[3] LUO Jintao;PAN Yaozhen;YANG Jing(Guizhou Medical University,Guiyang 550004,China;Department of Hepatobiliary Surgery,Affiliated Cancer Hospital of Guiyang Medical University,Guiyang 550004,China;Department of Obstetrics and Gynecology,Guizhou Provincial People′s Hospital,Guiyang 550004,China)

机构地区：[1]贵州医科大学,贵阳550004 [2]贵州医科大学附属肿瘤医院肝胆外科,贵阳550004 [3]贵州省人民医院妇产科,贵阳550004

出　　处：《医学综述》2022年第13期2668-2672,共5页Medical Recapitulate

基　　金：贵州省科技计划项目(黔科合基础〔2020〕1Y149)。

摘　　要：随着人们生命质量的提高和饮食习惯的改变,我国胆囊结石和2型糖尿病(T2DM)发病呈现增长趋势,临床T2DM伴发胆囊结石的患者并不少见,因独特的病理生理机制,使得T2DM伴发胆囊结石的治疗风险较单纯胆囊结石患者更高,所以对T2DM伴发胆囊结石疾病机制的研究很有必要。T2DM是胆囊结石发病的危险因素之一,且T2DM患者易患胆囊结石可能与胰岛素抵抗、瘦素抵抗、脂联素缺乏、肠道菌群紊乱、胆囊功能障碍等因素有关。With the improvement of people′s quality of life and the change of eating habits,the incidence of cholecystolithiasis and type 2 diabetes mellitus(T2DM)in China are showing an increasing trend,and it is not uncommon to see patients with T2DM combined with cholecystolithiasis in clinical work.Because of the unique pathophysiological mechanism,the patients with T2DM and cholecystolithiasis have a higher risk of treatment than the patients with simple cholecystolithiasis,therefore it is quite necessary to study the disease mechanism.T2DM is one of the risk factors for the development of cholecystolithiasis,and the susceptibility of the T2DM patients to gallbladder stones may be related to insulin resistance,leptin resistance,adiponectin deficiency,intestinal flora disorders,gallbladder dysfunction and other factors.

关 键 词：2型糖尿病 胆囊结石 发病机制 

分 类 号：R587.1[医药卫生—内分泌]