微RNA在心肌缺血再灌注损伤中的作用及机制的研究进展  

Research Progress of Role and Mechanism of MicroRNA in Myocardial Ischemia-reperfusion Injury

作　　者：汪再兴 陈橙 吴昊 霍倩 赵燕 张宏 WANG Zaixing;CHEN Cheng;WU Hao;HUO Qian;ZHAO Yan;ZHANG Hong(Department of Cardiovascular Medicine,Affiliated Hospital of Kunming University of Science and Technology/the First People′s Hospital of Yunnan Province,Kunming 650032,China;Department of Geratology,Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032,China;Faculty of Life Science,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学附属医院云南省第一人民医院心内科,昆明650032 [2]昆明理工大学附属医院老年医学科,昆明650032 [3]昆明理工大学生命科学院,昆明650500

出　　处：《医学综述》2022年第15期2945-2951,共7页Medical Recapitulate

基　　金：云南省科技厅科技计划项目(202101AY070001-268)。

摘　　要：目前,血运重建是急性心肌梗死最主要的治疗方法,血管开通后导致的心肌缺血再灌注损伤(MIRI)被认为在冠心病中具有有害作用。微RNA(miRNA)在MIRI的发展中至关重要。miRNA已被确定为MIRI中的关键调节分子,调控miRNA的异常表达可以减轻MIRI。目前miRNA在MIRI中的调控机制尚不完全清楚。MIRI时miRNA的表达水平发生变化,通过调节相关靶基因减少MIRI,为MIRI的预防和治疗提供新的靶点。For acute myocardial infarction,revascularization is currently the main treatment method.Myocardial ischemia-reperfusion injury(MIRI)caused by vascular opening is considered to have harmful effects in coronary heart disease.MicroRNA(miRNA)is essential in the development of MIRI.miRNA has been identified as a key regulatory molecule in MIRI,and regulating the abnormal expression of miRNA can alleviate MIRI.At present,the regulatory mechanism of miRNA in MIRI is not fully understood yet.The expression level of miRNA changes during MIRI,and regulating related target genes reduces MIRI and provides new targets for the prevention and treatment of MIRI.

关 键 词：冠心病 急性心肌梗死 心肌缺血再灌注损伤 微RNA 

分 类 号：R541[医药卫生—心血管疾病] Q74[医药卫生—内科学]